| Identification | Back Directory | [Name]
Lenperone | [CAS]
24677-86-9 | [Synonyms]
AHR-2277
Nsc303301
Lenperone HCl
4-[4-(4-fluorobenzoyl)piperidin-1-ium-1-yl]-1-(4-fluorophenyl)butan-1-one
Butyrophenone, 4'-fluoro-4-[4-(p-fluorobenzoyl)piperidino]-, hydrochloride
1-Butanone, 4-[4-(4-fluorobenzoyl)-1-piperidinyl]-1-(4-fluorophenyl)-, hydrochloride | [Molecular Formula]
C22H24ClF2NO2 | [MDL Number]
MFCD01737494 | [MOL File]
24677-86-9.mol | [Molecular Weight]
407.89 |
| Hazard Information | Back Directory | [Uses]
Lenperone hydrochloride (AHR 2277) is an antipsychotic compound and a dopamine antagonist. Lenperone hydrochloride reduces gastroesophageal sphincter pressure of healthy dogs. Lenperone hydrochloride can be used for neurological disease research[1][2]. | [in vivo]
Lenperone hydrochloride (0.16 and 0.44 mg/kg; intramuscular injection; once) decreases mean gastroesophageal sphincter pressure (GESP) of healthy dogs[1].
Lenperone hydrochloride (0.5, 1.0 and 2.0 mg/kg; subcutaneous injection) shows antipsychotic effects with inducing a dose-dependently cataleptic state and reducing bilateral lesion of the nucleus interstitialis stria terminalis in rats with brain damage[2]. | Animal Model: | Healthy adult dogs[1] | | Dosage: | 0.16 and 0.44 mg/kg | | Administration: | Intramuscular injection; 0.16 and 0.44 mg/kg, once | | Result: | Effectively decreased gastroesophageal sphincter pressure (GESP) of dogs.
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| [References]
[1] Johnson SE, et al. Effect of lenperone hydrochloride on gastroesophageal sphincter pressure in healthy dogs. Can J Vet Res. 1989 Apr;53(2):248-50. PMID:2565757
[2] Costall B, Naylor RJ. Mesolimbic involvement with behavioural effects indicating antipsychotic activity. Eur J Pharmacol. 1974 Jun;27(1):46-58. DOI:10.1016/0014-2999(74)90201-5 |
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