| Identification | Back Directory | [Name]
Benzeneacetamide, 4-fluoro-α-methyl-N-[4-[4,5,6,7-tetrahydro-5-methyl-4-oxo-3-(phenylamino)-1H-pyrrolo[3,2-c]pyridin-2-yl]-2-pyridinyl]-, (αS)- | [CAS]
2468783-75-5 | [Synonyms]
BAY-888
Benzeneacetamide, 4-fluoro-α-methyl-N-[4-[4,5,6,7-tetrahydro-5-methyl-4-oxo-3-(phenylamino)-1H-pyrrolo[3,2-c]pyridin-2-yl]-2-pyridinyl]-, (αS)- | [Molecular Formula]
C28H26FN5O2 | [MOL File]
2468783-75-5.mol | [Molecular Weight]
483.55 |
| Chemical Properties | Back Directory | [Boiling point ]
776.0±60.0 °C(Predicted) | [density ]
1.335±0.06 g/cm3(Predicted) | [storage temp. ]
Store at 2-8°C, protect from light | [form ]
Solid | [pka]
12.77±0.70(Predicted) | [color ]
Off-white to light brown |
| Hazard Information | Back Directory | [Description]
BAY-888 exhibits IC50 value of 1.5 nM and 5.5 nM towards CSNK1A1 and CSNK1D, respectively. | [Uses]
BAY-888 is an orally active CSNK1A1 and CSNK1D inhibitor with IC50 of 1.5 nM and 5.5 nM, respectively. BAY-888 has antitumor activity[1][2]. | [References]
[1] Volker Schulze, et al. Substituted pyrrolo-pyridinone derivatives and therapeutic uses thereof. WO2022023337 A1.
[2] Steven M. Corsello, et al Abstract 3588: Discovery of potent and selective CSNK1A1 inhibitors for solid tumor therapy. Cancer Res 15 June 2022; 82 (12_Supplement): 3588. |
|
|