| Identification | Back Directory | [Name]
15N, 98%) CHEM.PURITY 97% | [CAS]
2483829-87-2 | [Synonyms]
15N, 98%) CHEM.PURITY 97%
VITAMIN B3 (NICOTINIC ACID) (2,6,CARBOXYL-13C3, 99% | [Molecular Formula]
C3C3H5NO2 | [MDL Number]
MFCD32641589 |
| Hazard Information | Back Directory | [Uses]
Niacin-15N,13C3 is the 13C and 15N labeled Niacin[1]. Niacin (Vitamin B3) is an orally active water-soluble B3 vitamin that is an essential nutrient for humans. Niacin (Vitamin B3) plays a key role in energy metabolism, cell signaling cascades regulating gene expression and apoptosis. Niacin (Vitamin B3) is also used in the study of cardiovascular diseases[2][3]. | [References]
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. DOI:10.1177/1060028018797110
[2] Bruckert E, et al. Meta-analysis of the effect of nicotinic acid alone or in combination on cardiovascular events and atherosclerosis. Atherosclerosis. 2010 Jun;210(2):353-61. DOI:10.1016/j.atherosclerosis.2009.12.023
[3] Wan P, et al. Pellagra: a review with emphasis on photosensitivity. Br J Dermatol. 2011 Jun164(6):1188-200. DOI:10.1111/j.1365-2133.2010.10163.x
[4] Ishii N, et al. Pellagra among chronic alcoholics: clinical and pathological study of 20 necropsy cases. J Neurol Neurosurg Psychiatry. 1981 Mar44(3):209-15. DOI:10.1136/jnnp.44.3.209
[5] Areeg M Almubarak, et al. Supplementation with Niacin during in vitro maturation improves the quality of porcine embryos. Theriogenology. 2021 Jul 15169:36-46. doi: 10.1016/j.theriogenology.2021.04.005. Epub 2021 Apr 18. DOI:10.1016/j.theriogenology.2021.04.005
[6] Nobuhiro Hirakawa, et al. Anti-invasive activity of niacin and trigonelline against cancer cells. Biosci Biotechnol Biochem. 2005 Mar69(3):653-8. DOI:10.1271/bbb.69.653
[7] Kang Cheng, et al. Antagonism of the prostaglandin D2 receptor 1 suppresses nicotinic acid-induced vasodilation in mice and humans. Proc Natl Acad Sci U S A. 2006 Apr 25103(17):6682-7. DOI:10.1073/pnas.0601574103 |
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