| Identification | Back Directory | [Name]
5,8,11,14,17-Eicosapentaenoic-19,19,20,20,20-d5 acid, ethyl ester, (5Z,8Z,11Z,14Z,17Z)- | [CAS]
2483831-19-0 | [Synonyms]
5,8,11,14,17-Eicosapentaenoic-19,19,20,20,20-d5 acid, ethyl ester, (5Z,8Z,11Z,14Z,17Z)- | [Molecular Formula]
C22H34O2 | [MOL File]
2483831-19-0.mol | [Molecular Weight]
330.51 |
| Hazard Information | Back Directory | [Description]
Eicosapentaenoic acid-d5 ethyl ester is intended for use as an internal standard for the quantification of eicosapentaenoic acid ethyl ester by GC- or LC-MS. Eicosapentaenoic acid (EPA) ethyl ester is an esterified form of the ω-3 fatty acid EPA . Dietary administration of EPA ethyl ester (41.4 g/100 g of total dietary fatty acids) increases the ex vivo activity of hepatic β-oxidation enzymes.1,2 It also reduces total hepatic triglyceride levels and increases the ω-3 fatty acid content of hepatic triglycerides and phospholipids, as well as increases the total levels of ω-3 fatty acids in rats. EPA ethyl ester (1 g/kg) reverses increases in plasma cholesterol levels and reduces circulating triglyceride levels in rats fed a high-fat diet.3 Formulations containing eicosapentaenoic acid ethyl ester have been used as adjuncts in the treatment of hypertriglyceridemia. | [Uses]
Eicosapentaenoic acid ethyl ester-d5-1 (EPA ethyl ester-d5) is deuterium labeled Eicosapentaenoic acid ethyl ester[1]. | [References]
1. Hong, D.D., Takahashi, Y., Kushiro, M., et al. Divergent effects of eicosapentaenoic and docosahexaenoic acid ethyl esters, and fish oil on hepatic fatty acid oxidation in the rat Biochim. Biophys. Acta 1635(1),29-36(2003).
2. Arachchige, P.G., Takahashi, Y., and Ide, T. Dietary sesamin and docosahexaenoic and eicosapentaenoic acids synergistically increase the gene expression of enzymes involved in hepatic peroxisomal fatty acid oxidation in rats Metabolism 55(3),381-390(2006).
3. Pérez-Echarri, N., Pérez-Matute, P., Marcos-Gómez, B., et al. Down-regulation in muscle and liver lipogenic genes: EPA ethyl ester treatment in lean and overweight (high-fat-fed) rats J. Nutr. Biochem. 20(9),705-714(2008). |
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