| Identification | Back Directory | [Name]
4,7,10,13,16,19-Docosahexaenoic acid, ethyl-1,1,2,2,2-d5 ester, (4Z,7Z,10Z,13Z,16Z,19Z)- | [CAS]
2692624-15-8 | [Synonyms]
4,7,10,13,16,19-Docosahexaenoic acid, ethyl-1,1,2,2,2-d5 ester, (4Z,7Z,10Z,13Z,16Z,19Z)- | [Molecular Formula]
C24H36O2 | [MOL File]
2692624-15-8.mol | [Molecular Weight]
356.55 |
| Hazard Information | Back Directory | [Uses]
Docosahexaenoic acid ethyl ester-d5 is the deuterium labeled Docosahexaenoic acid ethyl ester. Docosahexaenoic acid ethyl ester (Ethyl docosahexaenoate) is a 90% concentrated ethyl ester of docosahexaenoic acid manufactured from the microalgal oil. Docosahexaenoic acid ethyl ester enhances 6-hydroxydopamine-induced neuronal damage by induction of lipid peroxidation in mouse striatum. Docosahexaenoic acid (DHA) is a key component of the cell membrane, and its peroxidation is inducible due to the double-bond chemical structure. Docosahexaenoic acid has neuroprotective effects[1][2]. | [References]
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110
[2] Dahms I, et al. Safety of docosahexaenoic acid (DHA) administered as DHA ethyl ester in a 9-month toxicity study in dogs. Food Chem Toxicol. 2016;92:50-57. DOI:10.1016/j.fct.2016.03.024
[3] Kabuto H, et al. Docosahexaenoic acid ethyl ester enhances 6-hydroxydopamine-induced neuronal damage by induction of lipid peroxidation in mouse striatum. Neurochem Res. 2009;34(7):1299-1303. DOI:10.1016/j.ijpharm.2008.05.036 |
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