| Identification | Back Directory | [Name]
8Z,11Z,14Z,17Z-EICOSATETRAENOIC ACID | [CAS]
24880-40-8 | [Synonyms]
(8Z,11Z,14Z,17Z)-
ω-3 Arachidonic acid
OMEGA-3 ARACHIDONIC ACID
Omega-3 arachidonmic acid
8Z,11Z,14Z,17Z-EICOSATETRAENOIC ACID
all-cis-8,11,14,17-icosatetraenoic acid
(all-cis)-8,11,14,17-Eicosatetraenoic Acid
8,11,14,17-Eicosatetraenoic acid, (8Z,11Z,14Z,17Z)-
(all-cis)-8,11,14,17-Eicosatetraenoic Acid (10 mg/mL ethanol) | [Molecular Formula]
C20H32O2 | [MDL Number]
MFCD00216033 | [MOL File]
24880-40-8.mol | [Molecular Weight]
304.47 |
| Chemical Properties | Back Directory | [Fp ]
14 °C | [storage temp. ]
−20°C | [solubility ]
0.1 M Na2CO3: 1.7 mg/ml; DMF: >100 mg/ml; DMSO: >100 mg/ml; Ethanol: Miscible | [form ]
Colourless Solution | [Stability:]
Light Sensitive |
| Hazard Information | Back Directory | [Description]
ω-3 Arachidonic acid is a rare PUFA found in trace amounts in dietary sources. ω-3 Fatty acids are now known to be essential for infant growth and development and protect against heart disease, thrombosis, hypertension, and inflammatory and autoimmune disorders. In human platelet membranes, ω-3 arachidonic acid inhibits arachidonoyl-CoA synthetase with a Ki of 14 μM. It also inhibits arachidonoyl-CoA synthetase in calf brain extracts with an IC50 value of about 5 μM. | [Uses]
(all-cis)-8,11,14,17-Eicosatetraenoic Acid (ω-3 Arachidonic acid) is a rare PUFA found in trace amounts in dietary sources. ω-3 Fatty acids are known to be essential for infant development and protect against heart disease, hypertension, thrombosis, and autoimmune and inflammatory disorder. In human platelet membranes, ω-3 Arachidonic acid inhibits arachidonoyl-CoA synthetase. | [Definition]
ChEBI: All-cis-8,11,14,17-icosatetraenoic acid is an icosatetraenoic acid having four cis double bonds at positions 8, 11, 14 and 17. It has a role as a fungal metabolite. It is an icosatetraenoic acid and an omega-3 fatty acid. It is a conjugate acid of an all-cis-8,11,14,17-icosatetraenoate. | [storage]
Store at -20°C | [References]
[1] AP S. Omega-3 fatty acids in health and disease and in growth and development[J]. American Journal of Clinical Nutrition, 1991, 54 3: Pages 438-463. DOI: 10.1093/ajcn/54.3.438
[2] E J NEUFELD. Fatty acid structural requirements for activity of arachidonoyl-CoA synthetase.[J]. Journal of Lipid Research, 1984, 25 3: 288-293.
[3] REBECA CAIRES. Omega-3 Fatty Acids Modulate TRPV4 Function through Plasma Membrane Remodeling.[J]. Cell reports, 2017, 21 1: 246-258. DOI: 10.1016/j.celrep.2017.09.029 |
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