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506-32-1

506-32-1 Structure

506-32-1 Structure
IdentificationMore
[Name]

Arachidonic acid
[CAS]

506-32-1
[Synonyms]

20:4, CIS,CIS,CIS-CIS-5,8,11,14-EICOSATETRAENOIC ACID
5,8,11,14-ALL-CIS-EICOSATETRAENOIC ACID
5,8,11,14-EICOSATETRAENOIC ACID
5,8,11,14-EICOSATETRENOIC ACID
5,8,11,14-EICOSATETRENOIC ACID (5 CIS, 8 CIS, 11 CIS, 14 CIS)
5,8,11,14-ICOSATETRAENOIC ACID
5Z,8Z,11Z,14Z-EICOSATETRAENOIC ACID
ALL CIS-5,8,11,14-EICOSATETRAENOIC ACID
ARACHIDONIC ACID
ARACHIDONIC ACID, PORCINE LIVER
C20:4 (ALL CIS-5,8,11,14) ACID
CIS-5,8,11,14-EICOSATETRAENOIC ACID
CIS,CIS,CIS,CIS-5,8,11,14-EICOSATETRAENOIC ACID
DELTA 5 CIS 8 CIS 11 CIS 14 CIS EICOSATETRAENOIC ACID
EICOSA-5Z,8Z,11Z,14Z-TETRAENOIC ACID
icosa-5,8,11,14-tetraenoic acid
(5Z,8Z,11Z,14Z)-5,8,11,14-Icosatetraenoic acid
(all-Z)-5,8,11,14-Eicosatetraenoic acid
(all-z)-5,8,11,14-eicosatetraenoicacid
5,8,11,14-Eicosatetraenoic acid, (all-Z)-
[EINECS(EC#)]

208-033-4
[Molecular Formula]

C20H32O2
[MDL Number]

MFCD00004417
[Molecular Weight]

304.47
[MOL File]

506-32-1.mol
Chemical PropertiesBack Directory
[Appearance]

liquid
[Melting point ]

-49 °C (lit.)
[Boiling point ]

169-171 °C/0.15 mmHg (lit.)
[density ]

0.922 g/mL at 25 °C(lit.)
[refractive index ]

n20/D 1.4872(lit.)
[Fp ]

>230 °F
[storage temp. ]

−20°C
[solubility ]

ethanol: ≥10 mg/mL
[form ]

oil
[pka]

4.75±0.10(Predicted)
[color ]

colorless to light yellow
[Water Solubility ]

PRACTICALLY INSOLUBLE
[Usage]

An unsaturated omega-6 fatty acid constituent of the phospholipids of cell membranes
[Merck ]

765
[BRN ]

1713889
[Concentration]

1 mCi/ml
[Solvent]

Ethanol under argon
[Specific Activity]

200-240 Ci/mmol
[Stability:]

Light Sensitive, Temperature Sensitive
[InChIKey]

YZXBAPSDXZZRGB-DOFZRALJSA-N
[LogP]

6.99
[Uses]

arachidonic acid is an ingredient with skin-smoothing, emollient, and healing properties. Arachidonic acid is an omega-6 essential fatty acid naturally occurring in the skin and considered critical for appropriate skin metabolism. It is a constituent of vitamin F.
[CAS DataBase Reference]

506-32-1(CAS DataBase Reference)
[NIST Chemistry Reference]

Arachidonic acid(506-32-1)
Safety DataBack Directory
[Risk Statements ]

R19:May form explosive peroxides.
[Safety Statements ]

S24/25:Avoid contact with skin and eyes .
[RIDADR ]

UN1170 - class 3 - PG 2 - Ethanol
[WGK Germany ]

3
[RTECS ]

CE6675000
[F ]

8-10-23
[HS Code ]

29161900
[Toxicity]

dns-mus:mmr 10 mg/L CRNGDP 5,1123,84
Raw materials And Preparation ProductsBack Directory
[Raw materials]

Ethanol-->Hydrochloric acid-->Potassium hydroxide-->ZINC-->Bromide-->METHYL ARACHIDONATE-->ETHANOL-1,1,2,2-D4-AMINE
[Preparation Products]

Prostaglandin E1-->Prostaglandin E2-->EPA-->2-AG-->trans,trans-2,4-Decadien-1-al-->Arachidonic Acid N-HydroxysucciniMidyl Ester
Material Safety Data Sheet(MSDS)Back Directory
[msds information]

Icosa-5,8,11,14-tetraenoic acid(506-32-1).msds
Questions And AnswerBack Directory
[Description]

Arachidonic acid belongs to a kind of polyunsaturated omega-6 fatty acid, which is highly biologically relevant. It is abundantly distributed in brain, muscles and liver. It is the precursor for all prostaglandins, thromboxanes, and leukotrienes. Most cellular arachidonic acid is esterified in the membrane phospholipids. It is an important second messenger of cellular signalling participating in the regulation of signaling enzymes including PLC-γ, PLC-δ, and PKC-α, -β, and -γ isoforms. In addition, arachidonic acid acts as key inflammatory intermediate as well as avasodilator. Generally, the body can synthesize the arachidonic acid through linoleic acid. However, upon linoleic acid deficiency, it is necessary to supplement arachidonic acid from the diets. Food sources of arachidonic acid include meat, eggs and some fishes. Alternatively, we can also have arachidonic acid supplements.
[References]

http://www.fitday.com/fitness-articles/nutrition/healthy-eating/what-is-arachidonic-acid.html
https://en.wikipedia.org/wiki/Arachidonic_acid
https://www.caymanchem.com/product/90010
Hazard InformationBack Directory
[Chemical Properties]

In chemical structure, arachidonic acid is a carboxylic acid with a 20-carbon chain and four cis-double bonds; the first double bond is located at the sixth carbon from the omega end.
Some chemistry sources define 'arachidonic acid' to designate any of the eicosatetraenoic acids. However, almost all writings in biology, medicine and nutrition limit the term to all-cis-5,8,11,14- eicosatetraenoic acid.
[Chemical Properties]

liquid
[Definition]

ChEBI: A long-chain fatty acid that is a C20, polyunsaturated fatty acid having four (Z)-double bonds at positions 5, 8, 11 and 14.
[General Description]

A Certified Spiking Solution? suitable for use in mass spectrometry-based fatty acid testing applications such as assessment of cardiovascular disease risk and fatty acid deficiency, and detection and quantification of arachidonic acid in nutraceuticals and dietary supplements. Arachidonic acid (cis-5,8,11,14), sometimes referred to as AA or ARA, is a polyunsaturated omega-6 fatty acid. Studies suggests that ARA as well as other fatty acids can serve as biomarkers for cardiovascular disease, and nutritional and metabolic disorders.
[Biological Activity]

Endogenous free fatty acid released from phospholipids by phospholipase A 2 . Important cellular signaling mediator and precursor of eicosanoids. Metabolized by lipoxygenases, cyclooxygenases and cytochrome P450 monooxygenases.
[Biochem/physiol Actions]

Arachidonic acid stimulates adhesion of MDA-MB-435 human metastatic cancer cells to extracellular matrix molecules (collagen IV and vitronectin) .
[Safety Profile]

Poison by intravenous route.Experimental reproductive effects. Mutation datareported. When heated to decomposition it emits acridsmoke and irritating fumes.
[Carcinogenicity]

In vitro and in vivo studies indicate that inhibition of arachidonic acid metabolism inhibits the growth of malignant cells, including head and neck squamous cell carcinoma, and implicates arachadonic acid in facilitating the metastasis of these tumor cells. Arachidonic acid reaction with cyclooxygenase and lipoxygenases yield eicosanoids that can mediate prostate cancer proliferation and enhance both tumor vascularization and metastasis. Cytochrome P450 arachidonic acid epoxygenases promote cell proliferation and inhibit apoptosis in endothelial cells.
Spectrum DetailBack Directory
[Spectrum Detail]

Arachidonic acid(506-32-1)1HNMR
Arachidonic acid(506-32-1)IR1
Well-known Reagent Company Product InformationBack Directory
[Acros Organics]

Arachidonic acid, from porcine liver, 99%(506-32-1)
[Sigma Aldrich]

506-32-1(sigmaaldrich)
[TCI AMERICA]

Arachidonic Acid,>97.0%(GC)(506-32-1)
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