| Identification | Back Directory | [Name]
2-Pyrimidinamine, N-methyl-N-(3-methylphenyl)-4-pyrazolo[1,5-b]pyridazin-3-yl- | [CAS]
2493976-27-3 | [Synonyms]
Dyrk1A-IN-3
2-Pyrimidinamine, N-methyl-N-(3-methylphenyl)-4-pyrazolo[1,5-b]pyridazin-3-yl- | [Molecular Formula]
C18H16N6 | [MOL File]
2493976-27-3.mol | [Molecular Weight]
316.36 |
| Hazard Information | Back Directory | [Uses]
Dyrk1A-IN-3 (Compound 8b), a highly selective dual-specificity tyrosine-regulated kinase 1A (DYRK1A) inhibitor, maintains high levels of DYRK1A binding affinity (IC50=76 nM). Dyrk1A-IN-3 can be used for the research of neurodegenerative disorders such as Alzheimer’s Disease, Huntington’s Disease, and Parkinson’s Disease[1]. | [References]
[1] Scott H Henderson, et al. Mining Public Domain Data to Develop Selective DYRK1A Inhibitors. ACS Med Chem Lett.?2020 Jun 30;11(8):1620-1626. DOI:10.1021/acsmedchemlett.0c00279 |
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