| Identification | Back Directory | [Name]
4-Quinazolinamine, 7-methoxy-N-[(3-methoxyphenyl)methyl]-2-[3-(3-pyridinyl)-1-pyrrolidinyl]- | [CAS]
2494198-61-5 | [Synonyms]
Miclxin
4-Quinazolinamine, 7-methoxy-N-[(3-methoxyphenyl)methyl]-2-[3-(3-pyridinyl)-1-pyrrolidinyl]- | [Molecular Formula]
C26H27N5O2 | [MOL File]
2494198-61-5.mol | [Molecular Weight]
441.52 |
| Chemical Properties | Back Directory | [Boiling point ]
670.3±65.0 °C(Predicted) | [density ]
1.261±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
7.76±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Miclxin (DS37262926) is a potent inhibitor of mutant β-catenin, involving in Wnt signaling pathway. Miclxin induces β-catenin-dependent apoptosis, leads to severe mitochondrial damage with the loss of mitochondrial membrane. Miclxin kills tumor via targeting to MIC60, a major components of the mitochondrial contact site and cristae organizing system (MICOS) complex[1]. | [References]
[1] Ikeda H, et al. Miclxin, a Novel MIC60 Inhibitor, Induces Apoptosis via Mitochondrial Stress in β-Catenin Mutant Tumor Cells. ACS Chem Biol. 2020 Aug 21;15(8):2195-2204. DOI:10.1021/acschembio.0c00381 |
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