| Identification | More | [Name]
3-METHOXY-4-METHYLBENZALDEHYDE | [CAS]
24973-22-6 | [Synonyms]
3-METHOXY-4-METHYLBENZALDEHYDE
3-METHOXY-P-TOLUALDEHYDE
TIMTEC-BB SBB008620
4-methyl-3-methoxybenzaldehdye | [Molecular Formula]
C9H10O2 | [MDL Number]
MFCD04114050 | [Molecular Weight]
150.17 | [MOL File]
24973-22-6.mol |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H302-H315-H319-H332-H335 | [Precautionary statements ]
P261-P280-P305+P351+P338 | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [HS Code ]
29122990 |
| Hazard Information | Back Directory | [Chemical Properties]
solid | [Synthesis Reference(s)]
Journal of Medicinal Chemistry, 32, p. 2210, 1989 DOI: 10.1021/jm00129a029 | [Synthesis]
Dess-Martin periodinane (3 g, 7.07 mmol) was slowly added to a solution of (3-methoxy-4-methylphenyl)methanol (1 g, 6.57 mmol) in dichloromethane (35 mL) at 0 °C. The reaction mixture was stirred continuously at 0°C for 0.5 hours. Subsequently, a portion of the dichloromethane was concentrated under reduced pressure, and the reaction mixture was diluted with ether and washed sequentially with saturated sodium bicarbonate solution, sodium thiosulfate solution and water. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to obtain 3-methoxy-4-methylbenzaldehyde in quantitative yield. | [References]
[1] Patent: WO2006/110668, 2006, A1. Location in patent: Page/Page column 65
[2] Journal of Medicinal Chemistry, 2012, vol. 55, # 15, p. 6948 - 6957
[3] Chemical and Pharmaceutical Bulletin, 1990, vol. 38, # 7, p. 1852 - 1856
[4] Journal of Medicinal Chemistry, 1989, vol. 32, # 9, p. 2210 - 2214
[5] Organic and Biomolecular Chemistry, 2015, vol. 13, # 37, p. 9564 - 9569 |
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