| Identification | Back Directory | [Name]
2-Pyrimidinamine, 5-bromo-4-(2-fluoro-4-nitrophenoxy)-N-(3,4,5-trimethoxyphenyl)- | [CAS]
2497409-01-3 | [Synonyms]
ULK1-IN-2
2-Pyrimidinamine, 5-bromo-4-(2-fluoro-4-nitrophenoxy)-N-(3,4,5-trimethoxyphenyl)- | [Molecular Formula]
C19H16BrFN4O6 | [MOL File]
2497409-01-3.mol | [Molecular Weight]
495.26 |
| Chemical Properties | Back Directory | [Boiling point ]
568.1±60.0 °C(Predicted) | [density ]
1.563±0.06 g/cm3(Predicted) | [storage temp. ]
4°C, away from moisture and light | [form ]
Solid | [pka]
1.02±0.10(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
ULK1-IN-2 (compound 3s) is a potent ULK1 inhibitor. ULK1-IN-2 shows highest cytotoxic effect against cancer cell lines, with IC50 of 1.94 μM in A549. ULK1-IN-2 can induce apoptosis and simultaneously block autophagy, and can be used to study NSCLC (Non-small cell lung cancer)[1]. | [IC 50]
ULK1 | [References]
[1] Sun D, Yang Z, Zhen Y, et al. Discovery of 5-bromo-4-phenoxy-N-phenylpyrimidin-2-amine derivatives as novel ULK1 inhibitors that block autophagy and induce apoptosis in non-small cell lung cancer. Eur J Med Chem. 2020;208:112782. DOI:10.1016/j.ejmech.2020.112782 |
|
|