| Identification | Back Directory | [Name]
Clobetasol | [CAS]
25122-41-2 | [Synonyms]
Clobetasol
ClobetasolBase
Clobetasol USP/EP/BP
Clobetasol Impurity G
CLOBETASOLE PROPIONATE
CLOBESTASOL PROPIONATE
CLOBETASOL-17-PROPIONATE
Betamethasone Impurity B
Clobetasol impurity G (PhEur)
Clobetasol Propionate EP IMP G
Clobetasol (1.0 mg/mL in Methanol)
21-Chloro-9-fluoro-11beta,17-dihydr
Clobetasol Propionate EP Impurity G
Clobetasol (Betamethasone Impurity B)
Clobetasol Propionate 25122-46-7 / Base
Clobetasol (Betamethasone EP Impurity B)
Betamethasone Impurity 2（Betamethasone EP Impurity B）
Clobetasol Propionate EP Impurity G/Betamethasone EP Impurity B
Clobetasol Propionate Impurity 7(Clobetasol Propionate EP Impurity G)
Clobetasol Propionate Impurity-G (EP)/ Betamethasone Impurity B (EP)
Betamethasone Impurity B (EP)/ Clobetasol Propionate Impurity-G (EP)
21-Chloro-9-fluoro-11β,17-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione
(11β,16β)-21-Chloro-9-fluoro-11,17-dihydroxy-16-methylpregna-1,4-diene-3,20-dione
Pregna-1,4-diene-3,20-dione, 21-chloro-9-fluoro-11,17-dihydroxy-16-methyl-, (11β,16β)-
17-(2-Chloroacetyl)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-6,7,8, 11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
Betamethasone impurity 1/Betamethasone EP Impurity B/Clobetasol/21-Chloro-9-fluoro-11?,17-dihydroxy-16?-methylpregna-1,4-diene-3,20-dione | [EINECS(EC#)]
246-633-8 | [Molecular Formula]
C22H28ClFO4 | [MDL Number]
MFCD00058499 | [MOL File]
25122-41-2.mol | [Molecular Weight]
410.91 |
| Chemical Properties | Back Directory | [Melting point ]
220-222°C | [Boiling point ]
555.1±50.0 °C(Predicted) | [density ]
1.32±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C Freezer | [solubility ]
Acetone (Slightly), DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
12.03±0.70(Predicted) | [color ]
White to Light Brown | [Henry's Law Constant]
6.2×104 mol/(m3Pa) at 25℃, HSDB (2015) | [InChIKey]
FCSHDIVRCWTZOX-IVGDLNKNNA-N | [SMILES]
F[C@]12[C@H](C[C@@]3([C@@](O)(C(=O)CCl)[C@@H](C)C[C@@]3([H])[C@]1([H])CCC1=CC(=O)C=C[C@]21C)C)O |&1:1,2,4,5,11,14,16,26,r| |
| Hazard Information | Back Directory | [Chemical Properties]
White to Off-White Solid | [Originator]
Dermovate,Glaxo,UK,1973 | [Uses]
Atorvastatin Intermediate | [Uses]
Topical corticosteroid. Glucocorticoid; anti-inflammatory. | [Definition]
ChEBI: A 3-oxo-Delta1,Delta4-steroid that is 16beta-methylpregna-1,4-diene-3,20-dione bearing hydroxy groups at the 11beta and 17alpha posit
ons, fluorine at position 9, and a chlorine substituent at position 21. It is used as its 17alpha-propionate ester to treat various skin disorders, including exzema and psoriasis. | [Manufacturing Process]
A solution of betamethasone 21-methanesulfonate (4 g) in dimethylformamide
(25 ml) was treated with lithium chloride (4 g) and the mixture heated on the
steam bath for 30 minutes. Dilution with water gave the crude product which
was recrystallized to afford the title compound, MP 226°C.
Clobetasol is usually converted to the propionate as the useful form by
reaction with propionic anhydride.
| [Brand name]
Clobex (Galderma); Clobex (Galderma);
Embeline (Healthpoint); Olux (Connetics); Temovate
(Altana). | [Therapeutic Function]
Corticosteroid, Antiinflammatory |
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