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251356-45-3

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251356-45-3 Structure

251356-45-3 Structure
IdentificationBack Directory
[Name]

SU 16f
[CAS]

251356-45-3
[Synonyms]

SU 16f
PDGFR Tyrosine Kinase Inhibitor VII - CAS 251356-45-3 - Calbiochem
(Z)-3-(2,4-Dimethyl-5-((2-oxo-6-phenylindolin-3-ylidene)methyl)-1H-pyrrol-3-yl)propanoic acid
5-[1,2-Dihydro-2-oxo-6-phenyl-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoicacid
1H-Pyrrole-3-propanoic acid, 5-[(1,2-dihydro-2-oxo-6-phenyl-3H-indol-3-ylidene)methyl]-2,4-dimethyl-
[Molecular Formula]

C24H22N2O3
[MDL Number]

MFCD03452699
[MOL File]

251356-45-3.mol
[Molecular Weight]

386.44
Chemical PropertiesBack Directory
[Boiling point ]

661.7±55.0 °C(Predicted)
[density ]

1.292±0.06 g/cm3(Predicted)
[storage temp. ]

Store at RT
[solubility ]

Soluble to 100 mM in DMSO
[form ]

Dark orange solid
[pka]

4?+-.0.10(Predicted)
[color ]

Yellow to orange
[InChI]

1S/C24H22N2O3/c1-14-18(10-11-23(27)28)15(2)25-21(14)13-20-19-9-8-17(12-22(19)26-24(20)29)16-6-4-3-5-7-16/h3-9,12-13,25H,10-11H2,1-2H3,(H,26,29)(H,27,28)/b20-13-
[InChIKey]

APYYTEJNOZQZNA-MOSHPQCFSA-N
Safety DataBack Directory
[WGK Germany ]

WGK 1
[Storage Class]

11 - Combustible Solids
Hazard InformationBack Directory
[Uses]

SU 16f is used in the synthetic preparation of [(Dihydrooxoindolylidene)methyl]pyrrolepropanoic Acid as a tyrosine kinase inhibitor.
[General Description]

A cell-permeable indolinone compound that acts as a potent, ATP site-targeting PDGFR inhibitor (IC50 = 10 nM against PDGFRβ), while affecting Flk-1/KDR/ VEGFR2, FGFR1, and EGFR only at much higher concentrations (IC50 = 0.14, 2.29, and >100 μM, respectively). Reported to selectively inhibit PDGFβ- over EGF-stimulated proliferation in EGFR-expressing NIH 3T3 cultures (IC50 = 0.11 and 21.9 μM, respectively) and exhibit much weaker potency against the proliferation of HUVEC cells upon FGF or VEGF stimulation (IC50 = 10 μM).
[IC 50]

PDGFRβ: 10 nM (IC50); PDGFR2: 140 nM (IC50); PDGFR1: 2.29 μM (IC50)
[storage]

Store at RT
Spectrum DetailBack Directory
[Spectrum Detail]

SU 16f(251356-45-3)1HNMR
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