| Identification | Back Directory | [Name]
SU 16f | [CAS]
251356-45-3 | [Synonyms]
SU 16f
PDGFR Tyrosine Kinase Inhibitor VII - CAS 251356-45-3 - Calbiochem
(Z)-3-(2,4-Dimethyl-5-((2-oxo-6-phenylindolin-3-ylidene)methyl)-1H-pyrrol-3-yl)propanoic acid
5-[1,2-Dihydro-2-oxo-6-phenyl-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoicacid
1H-Pyrrole-3-propanoic acid, 5-[(1,2-dihydro-2-oxo-6-phenyl-3H-indol-3-ylidene)methyl]-2,4-dimethyl- | [Molecular Formula]
C24H22N2O3 | [MDL Number]
MFCD03452699 | [MOL File]
251356-45-3.mol | [Molecular Weight]
386.44 |
| Chemical Properties | Back Directory | [Boiling point ]
661.7±55.0 °C(Predicted) | [density ]
1.292±0.06 g/cm3(Predicted) | [storage temp. ]
Store at RT | [solubility ]
Soluble to 100 mM in DMSO | [form ]
Dark orange solid | [pka]
4?+-.0.10(Predicted) | [color ]
Yellow to orange | [InChI]
1S/C24H22N2O3/c1-14-18(10-11-23(27)28)15(2)25-21(14)13-20-19-9-8-17(12-22(19)26-24(20)29)16-6-4-3-5-7-16/h3-9,12-13,25H,10-11H2,1-2H3,(H,26,29)(H,27,28)/b20-13- | [InChIKey]
APYYTEJNOZQZNA-MOSHPQCFSA-N |
| Hazard Information | Back Directory | [Uses]
SU 16f is used in the synthetic preparation of [(Dihydrooxoindolylidene)methyl]pyrrolepropanoic Acid as a tyrosine kinase inhibitor. | [General Description]
A cell-permeable indolinone compound that acts as a potent, ATP site-targeting PDGFR inhibitor (IC50 = 10 nM against PDGFRβ), while affecting Flk-1/KDR/ VEGFR2, FGFR1, and EGFR only at much higher concentrations (IC50 = 0.14, 2.29, and >100 μM, respectively). Reported to selectively inhibit PDGFβ- over EGF-stimulated proliferation in EGFR-expressing NIH 3T3 cultures (IC50 = 0.11 and 21.9 μM, respectively) and exhibit much weaker potency against the proliferation of HUVEC cells upon FGF or VEGF stimulation (IC50 = 10 μM). | [IC 50]
PDGFRβ: 10 nM (IC50); PDGFR2: 140 nM (IC50); PDGFR1: 2.29 μM (IC50) | [storage]
Store at RT |
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| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
cjbscvictory
|
| Tel: |
13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
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