ChemicalBook--->CAS DataBase List--->254877-67-3

254877-67-3

254877-67-3 Structure

254877-67-3 Structure
IdentificationBack Directory
[Name]

Ataciguat
[CAS]

254877-67-3
[Synonyms]

HMR 1766
Ataciguat
Ataciguat (HMR-1766
5-Chloro-2-[[(5-chloro-2-thienyl)sulfonyl]amino]-N-[4-(4-morpholinylsulfonyl)phenyl]benzamide
Benzamide, 5-chloro-2-[[(5-chloro-2-thienyl)sulfonyl]amino]-N-[4-(4-morpholinylsulfonyl)phenyl]-
[Molecular Formula]

C21H19Cl2N3O6S3
[MDL Number]

MFCD09837865
[MOL File]

254877-67-3.mol
[Molecular Weight]

576.49
Chemical PropertiesBack Directory
[density ]

1.613±0.06 g/cm3(Predicted)
[pka]

5.70±0.50(Predicted)
Hazard InformationBack Directory
[Uses]

Ataciguat, formerly referred to as HMR-1766, a novel anthranilic acid derivative, belongs to a new structural class of sGC activators capable of activating the oxidized form of sGC. Ataciguat has been shown to improve endothelial function and to reduce platelet activation in exptl. diabetes. Chronic regular treatment with sGC activators such as ataciguat could therefore eventually constitute an effective therapy targeting deficient NO/cGMP signaling in hypertension, peripheral and coronary artery disease, heart failure, thrombosis and erectile dysfunction.
Spectrum DetailBack Directory
[Spectrum Detail]

Ataciguat(254877-67-3)1HNMR
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