| Identification | Back Directory | [Name]
RIBOSTAMYCIN SULFATE SALT | [CAS]
25546-65-0 | [Synonyms]
sf733
ribomycin
vistamycin
NSC 138925
dekamyciniv
hetangmycin
ribostamycin
antibioticsf733
RIBOSTAMYCIN SULPHATE
RIBOSTAMYCIN DISULFATE
RIBOSTAMYCIN SULFATE SALT
d-ribofuranosyl-(1-5))-2-deoxy-
RIBOSTAMYCIN SULFATE SALT USP/EP/BP
Ribostamycin (base and/or unspecified salts)
4-O-(2,6-Diamino-2,6-dideoxy-α-D-glucopyranosyl)-5-O-(β-D-ribofuranosyl)-2-deoxy-D-streptamine
4-O-[2,6-Diamino-2,6-dideoxy-α-D-glucopyranosyl]-5-O-(β-D-ribofuranosyl)-2-deoxy-D-streptamine
D-Streptamine, O-2,6-diamino-2,6-dideoxy-α-D-glucopyranosyl-(1→4)-O-[β-D-ribofuranosyl-(1→5)]-2-deoxy-
D-Streptamine, O-2,6-diamino-2,6-dideoxy-a-D-glucopyranosyl-(14)-O-[b-D-ribofuranosyl-(15)]-2-deoxy- (8CI, 9CI) | [EINECS(EC#)]
247-091-5 | [Molecular Formula]
C17H34N4O10 | [MDL Number]
MFCD00057496 | [MOL File]
25546-65-0.mol | [Molecular Weight]
454.47 |
| Chemical Properties | Back Directory | [Melting point ]
192-195°; mp 175-180° (dec) | [alpha ]
D23 +42° | [Boiling point ]
561.28°C (rough estimate) | [density ]
1.1751 (rough estimate) | [refractive index ]
1.6700 (estimate) | [storage temp. ]
2-8°C | [pka]
7.70(at 25℃) |
| Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
61-20/21/22 | [Safety Statements ]
53-22-36/37/39-45 | [WGK Germany ]
3 | [RTECS ]
WK2300000 | [Toxicity]
mouse,LD50,intracrebral,66800ug/kg (66.8mg/kg),BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLDLUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION,Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 2489, 1970. |
| Hazard Information | Back Directory | [Description]
Ribostamycin was found in the culture broth of Streptomyces ribosidificus by Meiji Seika Kaisha in 1970 in the course of screening aminoglycoside antibiotics. It is structurally related to neomycin but lacks the diaminoidose (glucose) moiety substituted on the ribose moiety. Ribostamycin is much less toxic than neomycin and shows strong activity against a variety of gram-positive and gram-negative bacteria, except Pseudomonas aeruginosa. It is used parenterally for therapy of urinary tract, respiratory tract, surgical, and other infections. | [Definition]
ChEBI: An amino cyclitol glycoside that is 4,6-diaminocyclohexane-1,2,3-triol having a 2,6-diamino-2,6-dideoxy-alpha-D-glucosyl residue attached at position 1 and a beta-D-ribosyl residue attache
at position 2. It is an antibiotic produced by Streptomyces ribosidificus (formerly S. thermoflavus). | [Mechanism of action]
Ribostamycin (SF-733) is produced by
Streptomyces ribosidificus. The free base is crystallized
from methanol solution. The structure
has been determined by chemical methods and
total synthesis has been undertaken . |
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cjbscvictory
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13348960310 13348960310 |
| Website: |
http://www.weikeqi-biotech.com/ |
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kemikalieimport
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+ 45 - 2034 3359 |
| Website: |
www.kemikalieimport.dk |
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