| Identification | Back Directory | [Name]
Thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione, 3-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-5-(3-methylphenyl)- | [CAS]
255713-53-2 | [Synonyms]
A-123189
Thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione, 3-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-5-(3-methylphenyl)- | [Molecular Formula]
C26H28N4O3S | [MOL File]
255713-53-2.mol | [Molecular Weight]
476.59 |
| Hazard Information | Back Directory | [Description]
A-123189 is a novel, selective and potent alpha1D antagonist. | [Uses]
A-123189 is a selective and potent α1D antagonist with Kis of 0.312 and 0.17 for human α1D and rat α1D, respectively. A-123189 displays selectivities between 10- to 20-fold for the α1D receptor over the human α1A and rat α1A receptors[1]. | [References]
[1] K P Briski, et al. Antagonism of type II, but not type I glucocorticoid receptors results in elevated basal luteinizing hormone release in male rats. Bioorganic & Medicinal Chemistry Letters, Volume 11, Issue 9, 7 May 2001, Pages 1119-1121. |
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