| Chemical Properties | Back Directory | [Boiling point ]
586.910±35.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.329±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 2mg/mL, clear | [form ]
powder | [pka]
11.028±0.10(predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Uses]
NVS MLLT-1 (compound 3) is a potent and selective MLLT1 inhibitor with Kd values of 0.18 μM, 0.24 μM, and 0.22 μM for wild-type, T1 mutants, and T3 mutants, respectively[1][2]. | [Biological Activity]
NVP-MLLT-1 is a potent and selective inhibitor against YEATS domain (YD) of MLLT1 (ENL/YEATS1) and MLLT3 (AF9/YEATS3). | [References]
[1] Ni X, et al. Structure and Inhibitor Binding Characterization of Oncogenic MLLT1 Mutants. ACS Chem Biol. 2021 Apr 16;16(4):571-578. DOI:10.1021/acschembio.0c00960
[2] Lee J, et al. The Promise and Peril of Chemical Probe Negative Controls. ACS Chem Biol. 2021 Apr 16;16(4):579-585. DOI:10.1021/acschembio.1c00036 |
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