| Identification | More | [Name]
4-Nonylphenylboronic acid | [CAS]
256383-45-6 | [Synonyms]
4-N-NONYLBENZENEBORONIC ACID
4-N-NONYLPHENYLBORONIC ACID
AKOS BRN-0129
4-N-NONYLBENZENEBORONIC ACID, 98+%
4-Nonylphenylboronic acid | [EINECS(EC#)]
-0 | [Molecular Formula]
C15H25BO2 | [MDL Number]
MFCD02093070 | [Molecular Weight]
248.17 | [MOL File]
256383-45-6.mol |
| Chemical Properties | Back Directory | [Melting point ]
82-85°C | [Boiling point ]
385.3±35.0 °C(Predicted) | [density ]
0.97±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
Soluble in DMSO (up to 30 mg/ml) | [form ]
solid | [pka]
8.72±0.16(Predicted) | [color ]
White | [Water Solubility ]
Insoluble in water. | [BRN ]
8215118 | [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months. | [CAS DataBase Reference]
256383-45-6(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [Hazard Note ]
Irritant | [HS Code ]
2931900090 |
| Hazard Information | Back Directory | [Description]
Nonylbenzeneboronic acid (CAS 256383-45-6) is a potent and selective inhibitor of fatty acid amide hydrolase (FAAH, the enzyme which hydrolyzes and deactivates anandamide), IC50=9.1 nM1. Also inhibits monoacylglycerol lipase (MAGL, the enzyme which hydrolyzes 2-arachidonoyl-glycerol), IC50=7.9 μM.1 | [Uses]
4-n-Nonylbenzeneboronic acid is a potent inhibitor of fatty acid amide hydrolase. It is also able to inhibit monoacylglycerol lipase (MAGL), which hydrolyzes 2-arachidonoyl glycerol (2-AG). | [in vitro]
4-(n-nonyl) benzeneboronic acid was synthezed as a potent inhibitor of faah, with an ic50 of 9.1 nm. 4-(n-nonyl) benzeneboronic acid was also found to be able to inhibit magl, which could hydrolyze 2-arachidonoyl glycerol, but at around 1000-fold higher concentration. moreover, it was found that as the most potent para-substituted compound, 4-(n-nonyl) benzeneboronic acid showed rather high pka of 9.1. in addition, the molecular docking was utilized to gain insight on the faah binding mode of 4-(n-nonyl) benzeneboronic acid and a putative binding mode was observed [1]. | [IC 50]
9.1 nm | [storage]
Store at -20°C | [References]
1) Minkkila?et al.?(2008),?Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase; J. Med. Chem.,?51?7057 |
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J & K SCIENTIFIC LTD.
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https://www.jkchemical.com |
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Alfa Aesar
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400-6106006 |
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http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
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400-0056266 |
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www.energy-chemical.com |
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