| Identification | Back Directory | [Name]
2-CYCLOPROPYLETHANOL | [CAS]
2566-44-1 | [Synonyms]
Cyclopropaneethanol
2-CYCLOPROPYLETHANOL
2-Cyclopropylethan-1-ol
(2-Hydroxyethyl)cyclopropane
2-Cyclopropylethanol, tech. 85%
Cyclopropaneethanol~(2-Hydroxyethyl)cyclopropane | [EINECS(EC#)]
680-717-9 | [Molecular Formula]
C5H10O | [MDL Number]
MFCD00040762 | [MOL File]
2566-44-1.mol | [Molecular Weight]
86.13 |
| Questions And Answer | Back Directory | [Synthesis]
Step 1: Preparation of Cyclopropylacetic Acid Methyl Ester Cyclopropylacetic acid (1.08 g; 10.57 mmol) was dissolved in 50 ml of methanol. The solution was cooled to 0°C, and 5 ml of 96% sulfuric acid was added dropwise with stirring. The solution was kept at room temperature overnight, then poured into ice water, alkalized with 30% ammonium hydrate, and finally extracted with dichloromethane. The organic layer was dried over sodium sulfate and evaporated to dryness to give 1.1 g of oily product (90% yield), which could be used as is without further purification. Step 2: Preparation of 2-CYCLOPROPYLETHANOL Sodium (85 mg; 0.004 mmol) was dissolved in 50 mL of methanol, and then 8.7 g (0.23 mol) of sodium borohydride was added. A solution of 3.7 g (0.032 mol) of methyl cyclopropyl acetate prepared according to Step 1 in 20 mL of methanol was added dropwise to the mixture with stirring. The reaction was refluxed for 6 hours, then 300 mL of brine was added, and the crude product was extracted with dichloromethane. The organic layer was dried over sodium sulfate and evaporated to dryness to give 1.52 g (55% yield) of the title compound. |
| Chemical Properties | Back Directory | [Boiling point ]
137-138°C | [density ]
0.975±0.06 g/cm3(Predicted) | [refractive index ]
1.4355 | [Fp ]
47°C | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
Chloroform, Methanol | [form ]
Oil | [pka]
15.16±0.10(Predicted) | [color ]
Clear Colorless | [Water Solubility ]
Miscible with water. | [BRN ]
2036028 |
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| Company Name: |
Alfa Aesar
|
| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
SPIRO PHARMA
|
| Telephone: |
|
| Website: |
www.spiropharma.com.cn |
|