| Chemical Properties | Back Directory | [density ]
1.44±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 100 mg/mL (150.21 mM);Ethanol: Insoluble | [form ]
Solid | [pka]
13.29±0.46(Predicted) | [color ]
White to off-white | [Water Solubility ]
Water: 13 mg/mL (19.53 mM) |
| Hazard Information | Back Directory | [Uses]
MM3122 is a selective type II transmembrane serine protease (TMPRSS2) inhibitor with an IC50 value of 0.34 nM. MM3122 effectively blocks TMPRSS2, thereby inhibiting the entry of SARS-CoV-2 and MERS-CoV into human cells[1]. | [Biological Activity]
MM3122 is a selective inhibitor of host cell serine protease TMPRSS2 (transmembrane protease serine 2) with IC50 of 0.34 nM against recombinant full-length TMPRSS2 protein. | [in vivo]
MM3122 (i.p., 0-100 mg/kg, daily, 7 days) has no adverse effects, no weight loss or changes in harvested organs (liver, spleen and kidney) compared to controls in NOD-scid IL2Rgnull (NSG) mice[1].
MM3122 (i.p., 16.7 mg/kg, once) has a half-life of 8.6 hours in plasma and 7.5 hours in lung of NSG mice[1].
| [storage]
Store at -20°C | [References]
[1] Mahoney M, et al. Proc Natl Acad Sci U S A. 2021 Oct 26;118(43):e2108728118. |
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