ChemicalBook--->CAS DataBase List--->2574390-27-3

2574390-27-3

2574390-27-3 Structure

2574390-27-3 Structure
IdentificationBack Directory
[Name]

INDEX NAME NOT YET ASSIGNED
[CAS]

2574390-27-3
[Synonyms]

MM3122
[Molecular Formula]

C31H39N9O6S
[MOL File]

2574390-27-3.mol
[Molecular Weight]

665.77
Chemical PropertiesBack Directory
[density ]

1.44±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO: 100 mg/mL (150.21 mM);Ethanol: Insoluble
[form ]

Solid
[pka]

13.29±0.46(Predicted)
[color ]

White to off-white
[Water Solubility ]

Water: 13 mg/mL (19.53 mM)
Hazard InformationBack Directory
[Uses]

MM3122 is a selective type II transmembrane serine protease (TMPRSS2) inhibitor with an IC50 value of 0.34 nM. MM3122 effectively blocks TMPRSS2, thereby inhibiting the entry of SARS-CoV-2 and MERS-CoV into human cells[1].
[Biological Activity]

MM3122 is a selective inhibitor of host cell serine protease TMPRSS2 (transmembrane protease serine 2) with IC50 of 0.34 nM against recombinant full-length TMPRSS2 protein.
[in vivo]

MM3122 (i.p., 0-100 mg/kg, daily, 7 days) has no adverse effects, no weight loss or changes in harvested organs (liver, spleen and kidney) compared to controls in NOD-scid IL2Rgnull (NSG) mice[1].
MM3122 (i.p., 16.7 mg/kg, once) has a half-life of 8.6 hours in plasma and 7.5 hours in lung of NSG mice[1].

[storage]

Store at -20°C
[References]

[1] Mahoney M, et al. Proc Natl Acad Sci U S A. 2021 Oct 26;118(43):e2108728118.
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