| Identification | Back Directory | [Name]
AWD-12-281 | [CAS]
257892-33-4 | [Synonyms]
AWD-12-281
GSK 842470
GSK-842470
AWD 12 281,AWD 12281
N-(3,5-Dichloro-pyridin-4-yl)-2-[1-(4-fluoro-benzyl)-5-hydroxy-1H-indol-3-yl]-2-oxo-acetamide
1H-Indole-3-acetamide, N-(3,5-dichloro-4-pyridinyl)-1-[(4-fluorophenyl)methyl]-5-hydroxy-α-oxo- | [Molecular Formula]
C22H14Cl2FN3O3 | [MDL Number]
MFCD04112942 | [MOL File]
257892-33-4.mol | [Molecular Weight]
458.27 |
| Hazard Information | Back Directory | [Uses]
AWD 12-281 is an orally active and highly selective phosphodiesterase 4 (PDE4) inhibitor (IC50 = 9.7 nM). AWD 12-281 is used in the study of allergic dermatitis, asthma, chronic obstructive pulmonary disease (COPD), and allergic rhinitis[1][2]. | [IC 50]
PDE4: 9.7 nM (IC50) | [References]
[1] Wolfgang B?umer, et al. AWD 12-281, a highly selective phosphodiesterase 4 inhibitor, is effective in the prevention and treatment of inflammatory reactions in a model of allergic dermatitis. J Pharm Pharmacol. 2003 Aug;55(8):1107-14. DOI:10.1211/0022357021585
[2] Regina Draheim, et al. Anti-inflammatory potential of the selective phosphodiesterase 4 inhibitor N-(3,5-dichloro-pyrid-4-yl)-[1-(4-fluorobenzyl)-5-hydroxy-indole-3-yl]-glyoxylic acid amide (AWD 12-281), in human cell preparations. J Pharmacol Exp Ther. 2004 Feb;308(2):555-63. DOI:10.1124/jpet.103.059097 |
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BOC Sciences
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1-631-485-4226; 16314854226 |
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