| Identification | Back Directory | [Name]
Hydroxy-PEG16-t-butyl ester | [CAS]
2592433-80-0 | [Synonyms]
Hydroxy-PEG16-t-butyl ester ISO 9001：2015 REACH | [Molecular Formula]
C39H78O19 | [MDL Number]
MFCD21363264 | [MOL File]
2592433-80-0.mol | [Molecular Weight]
851.03 |
| Hazard Information | Back Directory | [Biological Activity]
Hydroxy-PEG16-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [References]
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. |
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