ChemicalBook--->CAS DataBase List--->778596-26-2

778596-26-2

778596-26-2 Structure

778596-26-2 Structure
IdentificationBack Directory
[Name]

HO-PEG10-tBu
[CAS]

778596-26-2
[Synonyms]

778596-26-2
OH-PEG10-TBA
HO-PEG10-tBu
HO-PEG10-COOtBu
Hydroxy-PEG10-Boc
PEG11-t-butly ester
HO-PEG10-CH2CH2COOtBu
OH-PEG10-CH2CH2COOtBu
Hydroxy-PEG10-t-butly ester
Hydroxy-PEG10-t-butyl ester
Hydroxy-PEG10-t-butyl ester,HO-PEG10-tBu
HO-PEG10-CH2CH2COOtBu
tert-Butyl 1-Hydroxy-3,6,9,12,15,18,21,24,27,30-decaoxatritriacontan-33-oate
33-Hydroxy-4,7,10,13,16,19,22,25,28,31-decaoxatritriacontanoic acid 1,1-dimethylethyl ester
4,7,10,13,16,19,22,25,28,31-Decaoxatritriacontanoic acid, 33-hydroxy-, 1,1-dimethylethyl ester
[Molecular Formula]

C27H54O13
[MDL Number]

MFCD28385467
[MOL File]

778596-26-2.mol
[Molecular Weight]

586.71
Chemical PropertiesBack Directory
[solubility ]

Soluble in Water, DMSO, DMF, DCM
[form ]

Liquid
[color ]

Colorless to light yellow
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P305+P351+P338
Hazard InformationBack Directory
[Description]

Hydroxy-PEG10-t-butyl ester is a PEG linker containing a hydroxyl group with a t-butyl ester. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions.
[Uses]

Hydroxy-PEG10-Boc is extacted from patent CN108707228 (example 0024)[1]. Hydroxy-PEG10-Boc is a uncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Hydroxy-PEG10-Boc can be conjugated to Paclitaxel (HY-B0015) or docetaxel (HY-B0011)[2].
[References]

[1] Huli, et al. A kind of preparation method of hydroxyl polyethylene glycol propionic ester. Patent CN108707228A.
[2] Miller ML, et al. Synthesis of taxoids with improved cytotoxicity and solubility for use in tumor-specific delivery.J Med Chem. 2004 Sep 23;47(20):4802-5. DOI:10.1021/jm049705s
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