| Identification | Back Directory | [Name]
HO-PEG10-tBu | [CAS]
778596-26-2 | [Synonyms]
778596-26-2
OH-PEG10-TBA
HO-PEG10-tBu
HO-PEG10-COOtBu
Hydroxy-PEG10-Boc
PEG11-t-butly ester
HO-PEG10-CH2CH2COOtBu
OH-PEG10-CH2CH2COOtBu
Hydroxy-PEG10-t-butly ester
Hydroxy-PEG10-t-butyl ester
Hydroxy-PEG10-t-butyl ester,HO-PEG10-tBu
HO-PEG10-CH2CH2COOtBu
tert-Butyl 1-Hydroxy-3,6,9,12,15,18,21,24,27,30-decaoxatritriacontan-33-oate
33-Hydroxy-4,7,10,13,16,19,22,25,28,31-decaoxatritriacontanoic acid 1,1-dimethylethyl ester
4,7,10,13,16,19,22,25,28,31-Decaoxatritriacontanoic acid, 33-hydroxy-, 1,1-dimethylethyl ester | [Molecular Formula]
C27H54O13 | [MDL Number]
MFCD28385467 | [MOL File]
778596-26-2.mol | [Molecular Weight]
586.71 |
| Hazard Information | Back Directory | [Description]
Hydroxy-PEG10-t-butyl ester is a PEG linker containing a hydroxyl group with a t-butyl ester. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions. | [Uses]
Hydroxy-PEG10-Boc is extacted from patent CN108707228 (example 0024)[1]. Hydroxy-PEG10-Boc is a uncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Hydroxy-PEG10-Boc can be conjugated to Paclitaxel (HY-B0015) or docetaxel (HY-B0011)[2]. | [References]
[1] Huli, et al. A kind of preparation method of hydroxyl polyethylene glycol propionic ester. Patent CN108707228A.
[2] Miller ML, et al. Synthesis of taxoids with improved cytotoxicity and solubility for use in tumor-specific delivery.J Med Chem. 2004 Sep 23;47(20):4802-5. DOI:10.1021/jm049705s |
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