| Identification | Back Directory | [Name]
TM-25659 | [CAS]
260553-97-7 | [Synonyms]
TM-25659
3H-Imidazo[4,5-b]pyridine, 2-butyl-5-methyl-6-(3-pyridinyl)-3-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]- | [Molecular Formula]
C30H28N8 | [MDL Number]
MFCD31813711 | [MOL File]
260553-97-7.mol | [Molecular Weight]
500.6 |
| Chemical Properties | Back Directory | [Boiling point ]
768.0±70.0 °C(Predicted) | [density ]
1.29±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : ≥ 135 mg/mL (269.68 mM);Water : < 0.1 mg/mL (insoluble) | [form ]
Solid | [pka]
4.15±0.10(Predicted) | [color ]
White to off-white | [InChIKey]
KCOQNLYGMQJUJD-UHFFFAOYSA-N | [SMILES]
CC1=NC2=C(N=C(CCCC)N2CC3=CC=C(C4=CC=CC=C4C5=NN=NN5)C=C3)C=C1C6=CN=CC=C6 |
| Hazard Information | Back Directory | [Uses]
TM 25659 is a novel TAZ modulator that inhibited viability in Madin-Darby dog kidney cell and in human colorectal adenocarcinoma cell. | [Biological Activity]
Cell permeable: yes | [in vivo]
TM-25659 (50 mg/kg, i.p., every other day for 2 weeks) suppresses bone loss in vivo and decreases weight gain in an obesity model[1]. TM-25659 has a favourable pharmacokinetic profile in rats. The plasma concentration of TM-25659 declines with an approximate t1/2 of 7 or 10 h following i.v or p.o. administration respectively. The systemic clearance (CL) is 0.21 L×h-1×kg-1 and the volume of distribution at steady-state (1.91 L×h-1×kg-1) is larger than the volume of total body fluids[1]. | Animal Model: | C57BL6 mice (4- to 6-week-old )[1] | | Dosage: | 50 mg/kg | | Administration: | I.p., every other day for 2 weeks | | Result: | Attenuated weight gain in these obese mice[1]. |
| Animal Model: | Adult male Sprague-Dawley rats[1] | | Dosage: | 10 mg/kg | | Administration: | I.v. (2, 10 and 30 min), oral (15 and 30 min, and 1, 2, 4 and 8 h) | | Result: | Oral administration for 4 weeks moderately but significantly attenuated weight gain and partly restored BMD in the OVX rats[1]. |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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