| Identification | Back Directory | [Name]
Furo(3,4-b)furan-2,6(3H,4H)-dione, dihydro-3-methylene-4-octyl-, (+-)- | [CAS]
26057-70-5 | [Synonyms]
Furo(3,4-b)furan-2,6(3H,4H)-dione, dihydro-3-methylene-4-octyl-, (+-)-
Furo[3,4-b]furan-2,6(3H,4H)-dione, dihydro-3-methylene-4-octyl-, (3aR,4R,6aR)-rel- | [Molecular Formula]
C15H22O4 | [MOL File]
26057-70-5.mol | [Molecular Weight]
266.33 |
| Chemical Properties | Back Directory | [Melting point ]
55-56 °C | [Boiling point ]
458.2±45.0 °C(Predicted) | [density ]
1.10±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
A residue |
| Hazard Information | Back Directory | [Description]
Avenaciolide is a water-insoluble fungal metabolite originally isolated from A. avenaceus. It inhibits glutamate transport in isolated rat liver mitochondria (Ki = 8 μM). | [Uses]
Avenaciolide is an antifungal bis-γ-lactone found in Aspergillus avenaceus. Avenaciolide has also antibacterial action. Avenaciolide is a specific inhibitor of glutamate transport in rat liver mitochondria. Avenaciolide interferes with the ability of ADP to stimulate the rate of glutamate oxidation[1][2]. | [References]
[1] Castelo-Branco PA, et al. Synthesis and antifungal activity of aromatic bis-gamma-lactones analogous to avenaciolide. Chem Biodivers. 2007;4(12):2745-2754. DOI:10.1002/cbdv.200790223
[2] McGivan JD, Chappell JB. Avenaciolide: a specific inhibitor of glutamate transport in rat liver mitochondria. Biochem J. 1970;116(4):37P-38P. PMID:5435480 |
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