| Identification | Back Directory | [Name]
(R)-(+)-THALIDOMIDE | [CAS]
2614-06-4 | [Synonyms]
NSC 91729
(R)-(+)-THALIDOMIDE
6-dioxo-3-piperidyl)-n-(d-(+)-phthalimid
N-[(R)-2,6-Dioxopiperidine-3-yl]phthalimide
(+)-N-[(R)-2,6-Dioxo-3-piperidinyl]phthalimide
6-dioxo-3-piperidinyl)-3(2h)-dion(r)-1h-isoindole-2-(2
(3R)-3-(1,3-Dioxo-2H-isoindole-2-yl)piperidine-2,6-dione
(R)-2-(2,6-DIOXO-3-PIPERIDINYL)-1H-ISOINDOLE-1,3-(2H)-DIONE
R-(+)-2-(2,6-DIOXO-3-PIPERIDINYL)-1H-ISOINDOLE-1,3(2H)-DIONE
(+)-2-[(R)-2,6-Dioxo-3-piperidinyl]-1H-isoindole-1,3(2H)-dione | [Molecular Formula]
C13H10N2O4 | [MDL Number]
MFCD00210220 | [MOL File]
2614-06-4.mol | [Molecular Weight]
258.23 |
| Chemical Properties | Back Directory | [Appearance]
Needles | [Melting point ]
269-271°C | [Boiling point ]
401.48°C (rough estimate) | [density ]
1.2944 (rough estimate) | [refractive index ]
1.5300 (estimate) | [storage temp. ]
-20?C Freezer | [solubility ]
DMSO: soluble
| [form ]
solid
| [pka]
10.70±0.40(Predicted) | [color ]
white
| [InChI]
1S/C13H10N2O4/c16-10-6-5-9(11(17)14-10)15-12(18)7-3-1-2-4-8(7)13(15)19/h1-4,9H,5-6H2,(H,14,16,17)/t9-/m1/s1 | [InChIKey]
UEJJHQNACJXSKW-SECBINFHSA-N | [SMILES]
O=C1CC[C@@H](N2C(=O)c3ccccc3C2=O)C(=O)N1 |
| Hazard Information | Back Directory | [Chemical Properties]
Needles | [Uses]
Optically active isomer of Thalidomide, which inhibits FGF-induced angiogenesis. Inhibits replication of human immunodeficiency virus type 1. Teratogenic sedative | [Definition]
ChEBI: A 2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione that has R-configuration at the chiral centre. | [reaction suitability]
reagent type: ligand | [Biochem/physiol Actions]
(-)-Thalidomide selectively inhibits biosynthesis of tumor necrosis factor α (TNF-α). (R)-Thalidomide is called "safe enantiomer", but it can be converted in the body to (S)-isomer. |
| Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
61-22 | [Safety Statements ]
53-36/37/39-45 | [WGK Germany ]
3
| [RTECS ]
TI4925000
| [Storage Class]
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | [Hazard Classifications]
Acute Tox. 4 Oral
Repr. 1B |
|
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