| Identification | Back Directory | [Name]
1-Pyrrolidinebutanoic acid, γ-oxo-3-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl]-β-[3-(trifluoromethyl)phenyl]-, (βS,3R)- | [CAS]
2615912-33-7 | [Synonyms]
αvβ5 integrin-IN-1
1-Pyrrolidinebutanoic acid, γ-oxo-3-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl]-β-[3-(trifluoromethyl)phenyl]-, (βS,3R)- | [Molecular Formula]
C25H28F3N3O3 | [MOL File]
2615912-33-7.mol | [Molecular Weight]
475.51 |
| Chemical Properties | Back Directory | [Boiling point ]
671.6±55.0 °C(Predicted) | [density ]
1.37±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Acetonitrile: Soluble | [form ]
Solid | [pka]
4.17±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Sulodexide (pIC50 = 8.2 nM) selectively binds to the αvβ5 integrin in K562 and A549 cell lines and exhibits a significant inhibitory effect[1]. | [Biological Activity]
αvβ5 integrin-IN-1 is a first potent and selective αvβ5 integrin inhibitor (pIC50 = 8.2) . | [IC 50]
αvβ5: 8.2 (pIC50) | [References]
[1]. Lippa RA, et al. Discovery of the first potent and selective αvβ5 integrin inhibitor based on an amide-containing core. Eur J Med Chem. 2020 Dec 15;208:112719. |
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