| Identification | Back Directory | [Name]
PROPERICYAZINE | [CAS]
2622-26-6 | [Synonyms]
ic6002
rp8908
wh7508
6909rp
Aolept
6909 RP
WH 7508
RP 8908
RP 8909
IC 6002
f.i.6145
Nelactil
Nemactil
Neulactil
Neuleptil
skf20,716
F.I. 6145
bayer1409
Bayer 1409
SKF 20,716
pericyazine
Periciazine
Properazine
Periciazinum
Properciazine
PROPERICIAZINE
PROPERICYAZINE
Piperocyanomazine
Periciazine oxalate salt
Propericiazine (Periciazine)
10-[3-(4-Hydroxy-1-piperidinyl)propyl]-
2.4.5-Trichlorophenylacetate 1g [2622-26-6]
1-(3-(2-cyano-10-phenothiazinyl)propyl)-4-piperidino
cyano-3((hydroxy-4piperidyl-1)-3propyl)-10phenothiazine
2-Cyano-10-(3-(4-hydroxypiperidino)propyl)phenothiazine
4-Piperidinol, 1-(3-(2-cyano-10-phenothiazinyl)propyl)-
2-Cyano-10-(3-(4-hydroxy-1-piperidyl)propyl)phenothiazine
Cyano-3 ((hydroxy-4 piperidyl-1)-3 propyl)-10 phenothiazine
10-(3-(4-hydroxypiperidino)propyl)-phenothiazine-2-carbonitril
10-(3-(4-Hydroxypiperidino)propyl)phenothiazine-2-carbonitrile
Phenothiazine-2-carbonitrile, 10-[3-(4-hydroxypiperidino)propyl]-
10-[3-(4-Hydroxy-1-piperidinyl)propyl]-10H-phenothiazine-2-carbonitrile
10-(3-(4-Hydroxypiperidin-1-yl)propyl)-10H-phenothiazine-2-carbonitrile
10H-Phenothiazine-2-carbonitrile, 10-[3-(4-hydroxy-1-piperidinyl)propyl]-
4,6-dibromo-2,2-dimethyl-4,5,6,6a-tetrahydro-3aH-cyclopenta[d][1,3]dioxole
RP8909,antipsychotic,Dopamine Receptor,Pericyazine,psychosis,adrenolytic,anxiety,anticholinergic,RP-8909,inhibit,Inhibitor,extrapyramidal | [EINECS(EC#)]
220-071-3 | [Molecular Formula]
C21H23N3OS | [MDL Number]
MFCD00210348 | [MOL File]
2622-26-6.mol | [Molecular Weight]
365.49 |
| Chemical Properties | Back Directory | [Melting point ]
116-117° | [Boiling point ]
593.4±50.0 °C(Predicted) | [density ]
1.1198 (rough estimate) | [refractive index ]
1.6740 (estimate) | [storage temp. ]
2-8°C | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
14.87±0.20(Predicted) | [color ]
Light Yellow to Yellow | [Water Solubility ]
38.01mg/L(37 ºC) | [CAS DataBase Reference]
2622-26-6 |
| Hazard Information | Back Directory | [Chemical Properties]
Yellow Solid | [Uses]
Psychotherapeutic phenothiazine. Antipsychotic. | [Definition]
ChEBI: A member of the class of phenothiazines that is 10H-phenothiazine substituted by a 3-(4-hydroxypiperidin-1-yl)propyl group at the nitrogen atom and a carbonitrile group at position 2. Periciazine is a first generation antipsychotic. | [Uses]
Spectrophotometric reagent for palladium and ruthenium. | [Originator]
Aolept, Bayer Vital | [Manufacturing Process]
2-Cyano-10-(3-methanesulfonyloxypropyl)phenthiazine and 4hydroxypiperidine in toluene were heated under reflux with stirring. The reaction mixture was allowed to cool and water was added. The resulting toluene solution layer was decanted and washed twice with water. The toluene solution was then stirred with 5% hydrochloric acid. The hydrochloride of the desired phenthiazine base precipitated in gummy condition in the aqueous layer. This was decanted and treated with sodium hydroxide (density 1.33). It was then extracted three times with ethyl acetate. The extracts were dried over sodium sulfate, filtered and concentrated in vacuum. A resinous product was obtained. This product was dissolved in a mixture of benzene and cyclohexane and chromatographed on a column containing alumina. The chromatographed product was eluted successively with mixtures of benzene and cyclohexane and then with benzene and finally with a mixture of benzene and ethyl acetate. The eluates were evaporated to yield a crude product. This product was recrystallised from aqueous ethanol (40% water) and yielded 2cyano-10-[3-(4-hydroxy-1-piperidyl)propyl]phenthiazine as white crystals. | [Therapeutic Function]
Neuroleptic | [storage]
Store at -20°C | [Purification Methods]
It recrystallises from a saturated solution in cyclohexane. It is antipsychotic and is a sensitive reagent for Pd, Va, Ru, Rh and Au. [Gowda et al. Anal Chem 55 1816 1983, Anal Chim Acta 154 347 1983, Beilstein 27 III/IV 4110.] |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
22-36/37/38-20/21/22 | [Safety Statements ]
26-36 | [RTECS ]
SN7175000 | [Safety Profile]
Poison by ingestion,
intraperitoneal, intravenous, and
subcutaneous routes. Used as an
antipsychotic agent. When heated to
decomposition it emits very toxic fumes of
CN-, NOx, and SOx. See also NITRILES. | [Toxicity]
LD50 orally in rats: 395 mg/kg (Schafer) |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Finetech Industry Limited
|
| Telephone: |
+86-27-8746-5837 +86-18627785180 |
| Website: |
https://www.finetechnology-ind.com/ |
| Company Name: |
AFINE CHEMICALS LIMITED
|
| Telephone: |
+86-571-85134551 +86-18958018566 |
| Website: |
www.afinechem.com/index.html |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
|