| Identification | Back Directory | [Name]
15-ACETOXY-3ALPHA,4BETA-DIHYDROXY-12,13-EPOXYTRICHOTHEC-9-ENE | [CAS]
2623-22-5 | [Synonyms]
15-mas
NSC-267030
deacetylanguidin
Desacetylanguidine
15-ACETOXYSCIRPENOL
monoacetoxyscirpenol
15-ACETOXYSCIRPENDIOL
15-MONOACETYLSCIRPENOL
15-MONOACETOXYSCIRPENOL
12,13-Epoxytrichothec-9-ene-3α,4β,15-triol 15-acetate
15-acetoxy-3α,4β-dihydroxy-12,13-epoxytrichothec-9-ene
3α,4β-Dihydroxy-15-acetoxy-12,13-epoxytrichotheca-9-ene
Anguidine, desacetyl(15-acetoxyscirpene-3,4-diol-bl5732)
(3-alpha)-12,13-epoxytrichothec-9-ene-3,4,15-triol15-acetate
15-ACETOXY-3ALPHA,4BETA-DIHYDROXY-12,13-EPOXYTRICHOTHEC-9-ENE
4-beta,15-triol,12,13-epoxy-trichothec-9-ene-3-alph15-acetate
Trichothec-9-ene-3.α.,4.β.,15-triol, 12,13-epoxy-, 15-acetate
Trichothec-9-ene-3,4,15-triol, 12,13-epoxy-, 15-acetate, (3α,4β)-
Trichothec-9-ene-3.alpha.,4.beta.,15-triol, 12,13-epoxy-, 15-acetate
Trichothec-9-ene-3,4,15-triol, 12,13-epoxy-, 15-acetate, (3.alpha.,4.beta.)-
15-Acetoxyscirpendiol, 15-Acetoxy-3α,4β-dihydroxy-12,13-epoxytrichothec-9-ene
15 Acetoxyscirpenol (3alpha,4beta)-12,13-epoxy-trichothec-9-ene-3,4,15-triol 15-acetate
((2R,2S,3R,5R,5AR,9aR)-3-hydroxy-5,8-dimethyl-2,3,4,5,5a,6,7,9a-octahydrospiro[2,5-methanobenzo[b]oxepine-10,2-oxiran]-5a-yl)methyl acetate | [Molecular Formula]
C18H26O5 | [MDL Number]
MFCD00078774 | [MOL File]
2623-22-5.mol | [Molecular Weight]
322.4 |
| Chemical Properties | Back Directory | [Melting point ]
170-172 °C | [Boiling point ]
465.5±45.0 °C(Predicted) | [density ]
1.34±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C
| [solubility ]
≤10mg/ml in methanol;10mg/ml in dichloromethane | [form ]
powder | [pka]
13.72±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Chemical Properties]
Solid | [Hazard]
A poison by ingestion. A mild skin irritant. | [Uses]
15-Acetoxyscirpenol is a trichothecene mycotoxin and an apoptosis inducer. | [Biological Activity]
15-acetoxy scirpenol is a trichothecene mycotoxin which is produced predominantly by members of the fusarium genus [1]. 15-acetoxy scirpenol could induce apoptotic cell death in human jurkat t cells. mycotoxins of scirpenol belong to the trichothecene family which is mainly produced by the fungal species of the genus fusarium. acetoxylated scirpenol has very high toxicities in animals and humans. 15-acetoxy scirpenol exhibited cytotoxicity at a lower concentration (25 ng/ml). the 50% inhibitory concentration (ic50) values of 15-acetoxy scirpenol was 16.1 ng/ml [2]. in the jurkat t cells treated with 50 ng/ml of 15-acetoxyscirpenol (15-mas), the populations of externalized ps-positive and pi-negative cells were 32.0% [2]. | [IC 50]
Caspase | [References]
[1] peraica m, radic b, lucic a, et al. toxic effects of mycotoxins in humans[j]. bulletin of the world health organization, 1999, 77(9): 754-766.
[2] lee d h, park t, kim h w. induction of apoptosis by disturbing mitochondrial-membrane potential and cleaving parp in jurkat t cells through treatment with acetoxyscirpenol mycotoxins[j]. biological and pharmaceutical bulletin, 2006, 29(4): 648-654. |
| Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
25 | [Safety Statements ]
45 | [RIDADR ]
UN 2811 6.1/PG 3
| [WGK Germany ]
3
| [RTECS ]
YD0111000
| [HazardClass ]
6.1(a) | [PackingGroup ]
II | [HS Code ]
29329990 |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
cjbscvictory
|
| Telephone: |
13348960310 13348960310 |
| Website: |
www.weikeqi-biotech.com/ |
|