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26328-11-0

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26328-11-0 Structure

26328-11-0 Structure
IdentificationBack Directory
[Name]

S(-)-PINDOLOL
[CAS]

26328-11-0
[Synonyms]

MT-102
AGI-001
L-PINDOLOL
S(-)-PINDOLOL
(-)-PINDOLOL B-ADRENERGIC BLOCKING
(2S)-1-(1H-Indole-4-yloxy)-3-(isopropylamino)propane-2-ol
[S,(-)]-1-(1H-Indole-4-yloxy)-3-(isopropylamino)-2-propanol
(S)-1-(1H-INDOL-4-YLOXY)-3-[(1-METHYLETHYL)AMINO]-2-PROPANOL
(S)-1-(1H-Indole-4-yloxy)-3-[(1-methylethyl)amino]-2-propanol
2-Propanol, 1-(1H-indol-4-yloxy)-3-[(1-methylethyl)amino]-, (S)-
2-Propanol, 1-(1H-indol-4-yloxy)-3-[(1-Methylethyl)aMino]-, (2S)-
S(-)-Pindolol (S)-1-((1H-indol-4-yl)oxy)-3-(dimethylamino)propan-2-ol
2-Propanol, 1-(1H-indol-4-yloxy)-3-[(1-methylethyl)amino]-, (2S)- (9CI)
[Molecular Formula]

C14H20N2O2
[MDL Number]

MFCD00153863
[MOL File]

26328-11-0.mol
[Molecular Weight]

248.32
Chemical PropertiesBack Directory
[Boiling point ]

457.1±35.0 °C(Predicted)
[density ]

1.152±0.06 g/cm3(Predicted)
[storage temp. ]

Desiccate at +4°C
[solubility ]

0.1 M NaOH: 0.2 mg/mL
[form ]

solid
[pka]

13.94±0.20(Predicted)
[color ]

white
[Optical Rotation]

[α]23/D 4.38°, c = 1% in methanol(lit.)
Safety DataBack Directory
[WGK Germany ]

3
Hazard InformationBack Directory
[Uses]

(S)-(-)-Pindolol is a SR-1A/SR-1B antagonist.
[Definition]

ChEBI: (S)-(-)-pindolol is a pindolol. It is an enantiomer of a (R)-(+)-pindolol.
[Biological Activity]

5-HT 1A/1B ? receptor antagonist, with roughly equal affinity for each subtype. A partial agonist at mouse and human β 3 -adrenoceptors. More active enantiomer of pindolol (1-(1H-Indol-4-yloxy)-3-[(1-methylethyl)amino]-2-propanol ).
[in vivo]

l-Pindolol (15 mg/kg; i.p., pretreatment before [3H]-WAY 100635 injection) reduces [3H]-WAY 100635 accumulation of 5-HT1A receptor-containing brain areas[1].

Animal Model:Male Sprague Dawley rats[1]
Dosage:15 mg/kg
Administration:Intraperitoneal injection; 15 mg/kg, 20 min acute treatment or 24 h, 16 h and 20 min short-term treatment before [3H]-WAY 100635 injection
Result:Reduced [3H]-WAY 100635 accumulation in 5-HT1A receptor-containing brain areas, but showed no effect on the dorsal raphe nucleus (DRN), and the CA1 and CA3 hippocampal areas.
[storage]

Desiccate at +4°C
Spectrum DetailBack Directory
[Spectrum Detail]

S(-)-PINDOLOL(26328-11-0)1HNMR
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