| Chemical Properties | Back Directory | [Boiling point ]
393.8±37.0 °C(Predicted) | [density ]
0.961±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) | [solubility ]
Ethanol: 1 mg/ml | [pka]
12.49±0.20(Predicted) |
| Hazard Information | Back Directory | [Uses]
1(R)-(Trifluoromethyl)oleyl alcohol (compound (R)-24) is a trifluoromethyl alcohol derivative of Oleic acid (HY-N1446) with activity in multiple models of Friedreich ataxia (FRDA). 1(R)-(Trifluoromethyl)oleyl alcohol inhibits ferroptosis induced by Erastin (HY-15763) and decreases lipid peroxidation in NBT human myoblasts with frataxin (FXN) siRNA knockdown. 1(R)-(Trifluoromethyl)oleyl alcohol at 40 μM increases survival to 95% in a model of FRDA where a significant percentage of cell death is caused by FAC (HY-B1645) and BSO (HY-106376)[1]. | [References]
[1] M Grazia Cotticelli, et al. Identification of a Novel Oleic Acid Analog with Protective Effects in Multiple Cellular Models of Friedreich Ataxia. ACS Chem Neurosci. 2020 Sep 2;11(17):2535-2542. DOI:10.1021/acschemneuro.0c00323 |
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