| Identification | More | [Name]
Oleyl alcohol | [CAS]
143-28-2 | [Synonyms]
9-OCTADECEN-1-OL
CIS-9-OCTADECEN-1-OL
CIS-9-OCTADECENE-1-OL
DELTA 9 OLEYL ALCOHOL
JARCOL 95BJ
NOVOL
OCTADEC-9-EN-1-OL
OLEIC ALCOHOL
OLEYL ALCOHOL
(9Z)-9-Octadecen-1-ol
(z)-9-octadecen-1-o
(Z)-9-Octadecen-1-ol
9-Octadecen-1-ol, (Z)-
9-Octadecen-1-ol, cis-
9-Octadecen-1-ol,(Z)-
9-octadecene-1-ol
Adol 320
Adol 330
Adol 34
Adol 340 | [EINECS(EC#)]
205-597-3 | [Molecular Formula]
C18H36O | [MDL Number]
MFCD00002993 | [Molecular Weight]
268.48 | [MOL File]
143-28-2.mol |
| Chemical Properties | Back Directory | [Appearance]
liquid | [Melting point ]
0-5.0 °C (lit.) | [Boiling point ]
207 °C/13 mmHg (lit.) | [density ]
0.849 g/mL at 25 °C(lit.)
| [vapor pressure ]
10.64 hPa (195 °C) | [FEMA ]
4363 | [refractive index ]
n20/D 1.46(lit.)
| [Fp ]
>230 °F
| [storage temp. ]
−20°C
| [solubility ]
Soluble in ethanol (95%), and ether; practically
insoluble in water. | [form ]
Viscous Liquid | [pka]
15.20±0.10(Predicted) | [color ]
Clear almost colorless to yellow | [Odor]
fatty animal | [Stability:]
Stable. Combustible. Incompatible with strong acids, strong oxidizing agents. | [Odor Type]
fatty | [Water Solubility ]
Miscible with alcohol and ether. Slightly miscible with carbon tetrachloride. Immiscible with water. | [JECFA Number]
1637 | [Merck ]
14,6831 | [BRN ]
1723962 | [LogP]
7.07 at 25℃ | [Uses]
oleyl alcohol is an emollient, solvent, viscosity-increasing agent, and carrier employed in a wide variety of cosmetic formulations including makeup, skin care, and hand and body preparations. oleyl alcohol is an unsaturated fatty alcohol found in fish oils and can also be produced synthetically. According to some sources, it is comedogenic and has a mild irritancy potential. | [CAS DataBase Reference]
143-28-2(CAS DataBase Reference) | [NIST Chemistry Reference]
Oleyl Alcohol(143-28-2) | [EPA Substance Registry System]
143-28-2(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R38:Irritating to the skin. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
-
| [RTECS ]
RG4120000
| [TSCA ]
Yes | [HS Code ]
29052990 | [Hazardous Substances Data]
143-28-2(Hazardous Substances Data) | [Toxicity]
LD50 orally in Rabbit: > 5000 mg/kg |
| Hazard Information | Back Directory | [Chemical Properties]
Colorless to light yellow liquid; fatty aroma with animal undertones. | [Chemical Properties]
Colourless or light yellow liquid. | [Chemical Properties]
Oleyl alcohol occurs as a pale yellow oily liquid that gives off acrid
fumes when heated. | [Definition]
ChEBI: A long chain fatty alcohol that is octadecanol containing a double bond located at position 9 (the Z-geoisomer). | [Production Methods]
Oleyl alcohol occurs naturally in fish oils. Synthetically, it can be
prepared from butyl oleate by a Bouveault–Blanc reduction with
sodium and butyl alcohol. An alternative method of manufacture is
by the hydrogenation of triolein in the presence of zinc chromite. | [Brand name]
Witcohol 85 (Witco); Witcohol 90 (Witco). | [Aroma threshold values]
Fatty-type, medium strength odor. | [General Description]
Oleyl alcohol has been reported as an effective solvent for oil/water-type tacrolimus (FK506) cream formulation, useful for atopic dermatitis treatment. It was reported as diluting agent for Alamine 336. Palm oil esters derived from oleyl alcohol, have potential applications in the cosmetic and pharmaceutical industries due to the excellent wetting behavior of the esters without the oily feel. | [Flammability and Explosibility]
Nonflammable(100%) | [Pharmaceutical Applications]
Oleyl alcohol is mainly used in topical pharmaceutical formulations
and has been used in transdermal delivery formulations.It has
been utilized in the development of biodegradable injectable
thermoplastic oligomers,and in aerosol formulations of insulin
and albuterol.
Therapeutically, it has been suggested that oleyl alcohol may
exhibit antitumor properties via transmembrane permeation. | [Safety Profile]
A human skin and eye irritant. Aningredient in cosmetics. When heated to decomposition itemits acrid smoke and irritating fumes. | [Safety]
Oleyl alcohol is mainly used in topical pharmaceutical formulations
and is generally regarded as a nontoxic and nonirritant material at
the levels employed as an excipient. However, contact dermatitis
due to oleyl alcohol has been reported.
The results of acute oral toxicity and percutaneous studies in
animals with products containing 8% oleyl alcohol indicate a very
low toxicity. Formulations containing 8% or 20% oleyl alcohol
administered by gastric intubation, at doses up to 10 g/kg bodyweight,
caused no deaths and no toxic effects in rats. | [storage]
The bulk material should be stored in a well-closed container in a
cool, dry, place. | [Purification Methods]
Purify it by fractional crystallisation at -40o from acetone, then distil it under vacuum. [Beilstein 2 IV 2204.] | [Regulatory Status]
Included in the FDA Inactive Ingredients Database (topical
emulsions and ointments). Included in nonparenteral medicines
licensed in the UK. Included in the Canadian List of Acceptable
Non-medicinal Ingredients. |
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