| Identification | Back Directory | [Name]
Urea, N-(3-fluoro-2-methylphenyl)-N'-(8-hydroxy-1,1-dioxido-2H-1-benzothiopyran-7-yl)- | [CAS]
2647464-92-2 | [Synonyms]
CXCR2 antagonist 3
Urea, N-(3-fluoro-2-methylphenyl)-N'-(8-hydroxy-1,1-dioxido-2H-1-benzothiopyran-7-yl)- | [Molecular Formula]
C17H15FN2O4S | [MOL File]
2647464-92-2.mol | [Molecular Weight]
362.38 |
| Hazard Information | Back Directory | [Uses]
CXCR2 antagonist 3 (compound 11h) is a potent antagonist of CXC chemokine receptor 2 (CXCR2). CXCR2 antagonist 3 demonstrates double-digit nanomolar potencies against CXCR2 and significantly inhibited neutrophil infiltration into the air pouch. CXCR2 antagonist 3 reduces the infiltration of neutrophils and MDSCs and enhance the infiltration of CD3+ T lymphocytes into the Pan02 tumor tissues[1]. | [References]
[1] Dong Y, et al. Discovery of Benzocyclic Sulfone Derivatives as Potent CXCR2 Antagonists for Cancer Immunotherapy. J Med Chem. 2021;64(22):16626-16640. DOI:10.1021/acs.jmedchem.1c01219 |
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