CIAC001 (20 μg/kg, and 0.2 mg/kg, i.p, once daily for 7 days) dose-dependently attenuates Naloxone (HY-137279, opioid receptor antagonist) precipitated withdrawal jumps and significantly inhibits the development of morphine-induced behavioral sensitization during the induction period, in morphine-dependent mice[1].
CIAC001 (20 mg/kg, i.p, once daily for 7 days)has no apparent potential for memory decline or cognitive impairment in mice Y maze test[1].