| Identification | Back Directory | [Name]
4-[4-chloro-5-(3-fluoro-4-methoxy-phenyl)imidazol-1-yl]benzenesulfonam ide | [CAS]
265114-23-6 | [Synonyms]
UR8880
UR-8880
Cimicoxib
UR-8880 (Cimicoxib)
trade name: Cimalgex
4-[4-chloro-5-(3-fluoro-4-methoxy-phenyl)imidazol-1-yl]benzenesulfonam ide
4-(4-chloro-5-(3-fluoro-4-Methoxyphenyl)-1H-iMidazol-1-yl)benzene sulfonaMide
Benzenesulfonamide, 4-[4-chloro-5-(3-fluoro-4-methoxyphenyl)-1H-imidazol-1-yl]- | [Molecular Formula]
C16H13ClFN3O3S | [MDL Number]
MFCD09837875 | [MOL File]
265114-23-6.mol | [Molecular Weight]
381.81 |
| Chemical Properties | Back Directory | [Melting point ]
211-212 °C | [Boiling point ]
593.1±60.0 °C(Predicted) | [density ]
1.49±0.1 g/cm3(Predicted) | [storage temp. ]
Refrigerator | [solubility ]
DMSO (Sparingly), Methanol (Slightly) | [form ]
Solid | [pka]
9.78±0.10(Predicted) | [color ]
White to Off-White | [InChI]
InChI=1S/C16H13ClFN3O3S/c1-24-14-7-2-10(8-13(14)18)15-16(17)20-9-21(15)11-3-5-12(6-4-11)25(19,22)23/h2-9H,1H3,(H2,19,22,23) | [InChIKey]
KYXDNECMRLFQMZ-UHFFFAOYSA-N | [SMILES]
C1(S(N)(=O)=O)=CC=C(N2C=NC(Cl)=C2C2=CC=C(OC)C(F)=C2)C=C1 |
| Hazard Information | Back Directory | [Description]
Cimicoxib is a non-steroidal anti-inflammatory drug (NSAID) that inhibits COX-2 selectively over COX-1 (IC50s = 0.005 and 3.3 μM, respectively). It inhibits paw swelling by 93% in a rat model of adjuvant-induced arthritis when administered at a dose of 1 mg/kg. Cimicoxib (3 mg/kg, p.o.) inhibits carrageenan-induced decreases in paw withdrawal latency in the hot plate test in a rat model of hyperalgesia. Formulations containing cimicoxib have been used in the treatment of pain and inflammation associated with osteoarthritis or surgery in dogs. | [Uses]
Cimicoxib is a long-acting COX-2 Inhibitor and is developed as a non-steroidal anti-inflammatory veterinary drug used to treat dogs with inflammation and pain associated with osteoarthritis. | [Definition]
4-[4-chloro-5-(3-fluoro-4-methoxy-phenyl)imidazol-1-yl]benzenesulfonam ide is an imidazole substituted at positions 1, 4 and 5 by 4-aminosulfonylphenyl, chloro and 3-fluoro-4-methyoxyphenyl groups respectively. A selective cyclooxygenase 2 inhibitor, it is used in veterinary medicine for the control of pain and inflammation associat d with osteoarthritis in dogs.
| [IC 50]
COX-2 | [References]
[1] T.W. KIM . Pharmacokinetic profiles of the novel COX-2 selective inhibitor cimicoxib in dogs[J]. Veterinary journal, 2014, 200 1: Pages 77-81. DOI: 10.1016/j.tvjl.2013.12.020
[2] CARMEN ALMANSA. Synthesis and Structure?Activity Relationship of a New Series of COX-2 Selective Inhibitors: 1,5-Diarylimidazoles[J]. Journal of Medicinal Chemistry, 2003, 46 16: 3463-3475. DOI: 10.1021/jm030765s |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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