| Identification | Back Directory | [Name]
2-[((2',6'-DICHLORO-4'-HYDROXY)PHENYL)AMINO]BENZENEACETIC ACID | [CAS]
64118-84-9 | [Synonyms]
4-OHD
4'-OHD
Hydroxydiclofenac
4-HYDROXY DICLOFENAC
4'-HYDROXYDICLOFENAC
DICLOFENAC, 4'-HYDROXY-
4'-HYDROXYDICLOFENAC STANDARD
4′-Hydroxydiclofenac solution
2-(2,6-Dichloro-4-hydroxyanilino)benzeneacetic acid
(o-(2,6-dichloro-4-hydroxyanilino)phenyl)-aceticaci
(o-(2,6-dichloro-4-hydroxyanilino)phenyl)aceticacid
[2-(2,6-Dichloro-4-hydroxyanilino)phenyl]acetic acid
Benzeneacetic acid, 2-[(2,6-dichloro-4-hydroxyphenyl)aMino]-
2-[((2',6'-DICHLORO-4'-HYDROXY)PHENYL)AMINO]BENZENEACETIC ACID | [EINECS(EC#)]
200-835-2 | [Molecular Formula]
C14H11Cl2NO3 | [MDL Number]
MFCD01671980 | [MOL File]
64118-84-9.mol | [Molecular Weight]
312.15 |
| Chemical Properties | Back Directory | [Appearance]
Light Violet Solid | [Melting point ]
178-185°C dec. | [Boiling point ]
432.7±45.0 °C(Predicted) | [density ]
1.520±0.06 g/cm3(Predicted) | [Fp ]
2℃ | [storage temp. ]
−20°C
| [solubility ]
Soluble in DMSO, ethanol or methanol | [form ]
neat | [pka]
4.17±0.10(Predicted) | [color ]
White to off-white | [BRN ]
4198042 | [Stability:]
Light Sensitive | [Major Application]
clinical testing | [InChI]
1S/C14H11Cl2NO3/c15-10-6-9(18)7-11(16)14(10)17-12-4-2-1-3-8(12)5-13(19)20/h1-4,6-7,17-18H,5H2,(H,19,20) | [InChIKey]
KGVXVPRLBMWZLG-UHFFFAOYSA-N | [SMILES]
OC(=O)Cc1ccccc1Nc2c(Cl)cc(O)cc2Cl |
| Hazard Information | Back Directory | [Chemical Properties]
Light Violet Solid | [Uses]
A metabolite of Diclofenac, a nonsteroidal anti-inflammatory compound and cyclooxygenase (COX) inhibitor | [Uses]
A metabolite of Diclofenac, a nonsteroidal inflammatory compound and cyclooxygenase (COX) inhibitor. | [Definition]
ChEBI: An monocarboxylic acid that is the 4'-hydroxylated metabolite of diclofenac. | [Description]
4-hydroxy Diclofenac is a CYP2C9 metabolite of the NSAID diclofenac . By inhibiting COX and subsequently suppressing PGE2 synthesis, it demonstrates anti-inflammatory and analgesic properties. | [General Description]
4′-Hydroxydiclofenac is one of the metabolites of diclofenac, a nonsteroidal anti-inflammatory drug (NSAID) used in human and veterinary medicine. | [References]
[1] R J SAWCHUK. Analysis of diclofenac and four of its metabolites in human urine by HPLC.[J]. Pharmaceutical Research, 1995, 12 5: 756-762. DOI: 10.1023/a:1016276012891
[2] ü. YA?AR. The role of CYP2C9 genotype in the metabolism of diclofenac in vivo and in vitro[J]. European Journal of Clinical Pharmacology, 2001, 57 1: 729-735. DOI: 10.1007/s00228-001-0376-7
[3] R YAMAZAKI. Hydrolytic activity is essential for aceclofenac to inhibit cyclooxygenase in rheumatoid synovial cells.[J]. Journal of Pharmacology and Experimental Therapeutics, 1999, 289 2: 676-681.
[4] FENG ZHANG. Inhibition of drug-metabolizing enzymes by Jingyin granules: implications of herb–drug interactions in antiviral therapy[J]. Acta Pharmacologica Sinica, 2021, 43 4: 1072-1081. DOI: 10.1038/s41401-021-00697-2 |
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