| Identification | Back Directory | [Name]
CASPASE-9 | [CAS]
265294-58-4 | [Synonyms]
MCH6
ICE-LAP6
CASPASE-9
CASPASE-9, HUMAN
CASPASE 9 PROTEIN
FULL-LENGTH CASPASE-9
Mouse Caspase 9 elisa kit
CASPASE-9 HUMAN, RECOMBINANT
CASPASE-9, HUMAN, RECOMBINANT, E COLI
CASPASE-9 (HUMAN) (ACTIVE) (RECOMBINANT)
Caspase-9 beta (human MKN-74 cell isoenzyme beta) | [MDL Number]
MFCD02264369 |
| Hazard Information | Back Directory | [Biological Activity]
When cells receive apoptotic stimulisuch as activation of the TNFα/Fas cell surface receptorcaspase 8 activationBid processing and its translocation to the mitochondria ensue. As a result mitochondria release cytochrome c which then binds to Apaf-1the mammalian Ced-4 homologuetogether with dATP. The resultant complex recruits caspase 9 leading to its activation. It then cleaves downstream caspases such as caspase 36and 7initiating the caspase cascade. Caspase 9 exhibits basal activity. It can be further activated via interaction of its N-terminal prodomain with the activator protein Apaf-1 in the presence of cytochrome c and dATP. Caspases have been implicated in many disorders including cancerinflammatory diseaseneurodegenerative diseasesstroke and myocardial infarction. |
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