| Identification | Back Directory | [Name]
LY 43578 | [CAS]
26766-35-8 | [Synonyms]
LY 43578
Bis(4-chlorophenyl)(pyrimidine-5-yl)methanol
α,α-Bis(4-chlorophenyl)pyrimidine-5-methanol | [Molecular Formula]
C17H12Cl2N2O | [MDL Number]
MFCD30558653 | [MOL File]
26766-35-8.mol | [Molecular Weight]
331.2 |
| Chemical Properties | Back Directory | [Melting point ]
159-161 °C | [Boiling point ]
494.9±40.0 °C(Predicted) | [density ]
1.376±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
11.40±0.29(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
LY 43578 is an aromatase inhibitor. | [Uses]
LY43578 is an orally active aromatase inhibitor. LY43578 inhibits P-450-dependent p-nitroanisole O-demethylation and ethylmorphine N-demethylation in hepatic microsomes isolated from rat, with the IC50 of 0.3 and 5 μΜ, respectively. LY43578 can be used for neurological disorder study[1][2]. | [References]
[1] Lindstrom TD, et al. Disposition of the aromatase inhibitor LY56110 and associated induction and inhibition studies in rats, dogs, and monkeys. Fundam Appl Toxicol. 1987;8(4):595-604. DOI:10.1016/0272-0590(87)90144-8
[2] Gonzalez MI, et al. Injection of an aromatase inhibitor after the critical period of sexual differentiation. Pharmacol Biochem Behav. 1994;47(1):183-186. DOI:10.1016/0091-3057(94)90129-5 |
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