| Identification | Back Directory | [Name]
2,4-Quinazolinediamine, N2-[(4-chloro-2-methoxyphenyl)methyl]-N4-(5-ethyl-1H-pyrazol-3-yl)-5-methoxy- | [CAS]
2677786-61-5 | [Synonyms]
GRK6-IN-1
GRK6 inhibitor 18
GRK6-IN-1 (compound 18)
2,4-Quinazolinediamine, N2-[(4-chloro-2-methoxyphenyl)methyl]-N4-(5-ethyl-1H-pyrazol-3-yl)-5-methoxy- | [Molecular Formula]
C22H23ClN6O2 | [MOL File]
2677786-61-5.mol | [Molecular Weight]
438.91 |
| Chemical Properties | Back Directory | [Boiling point ]
679.5±65.0 °C(Predicted) | [density ]
1.369±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
14.07±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
GRK6-IN-1 (compound 18) is a potent inhibitor of G protein-coupled receptor kinase 6 (GRK6) with an IC50 of 120 nM. GRK6 is a critical kinase required for the survival of multiple myeloma (MM) cells. GRK6-IN-1 has the potential for the research of multiple myeloma[1]. | [References]
[1] Uehling DE, et al. Design, Synthesis, and Characterization of 4-Aminoquinazolines as Potent Inhibitors of the G Protein-Coupled Receptor Kinase 6 (GRK6) for the Treatment of Multiple Myeloma [published correction appears in J Med Chem. 2022 Jan 13;65(1):886-887]. J Med Chem. 2021;64(15):11129-11147. DOI:10.1021/acs.jmedchem.1c00506 |
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DC Chemicals
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021-58447131 13564518121 |
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InvivoChem
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13549236410 |
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https://www.invivochem.cn/ |
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