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2691796-83-3

2691796-83-3 Structure

2691796-83-3 Structure
IdentificationBack Directory
[Name]

BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride
[CAS]

2691796-83-3
[Synonyms]

BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride
[Molecular Formula]

C41H44Cl2N4O5
[MOL File]

2691796-83-3.mol
[Molecular Weight]

743.73
Chemical PropertiesBack Directory
[form ]

Solid
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride incorporates a ligand for PD-1/PD-L1 immune checkpoint, and a PROTAC linker. BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride can be used in the synthesis of PROTAC PD-1/PD-L1 degrader-1?(HY-131183). PROTAC PD-1/PD-L1 degrader-1 inhibits PD-1/PD-L1 interaction with an IC50 of 39.2 nM[1].
[References]

[1] Cheng B, Ren Y, Cao H, Chen J. Discovery of novel resorcinol diphenyl ether-based PROTAC-like molecules as dual inhibitors and degraders of PD-L1. Eur J Med Chem. 2020;199:112377. DOI:10.1016/j.ejmech.2020.112377
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