| Identification | Back Directory | [Name]
N-(4-CHLOROPHENYL)-2-[(PYRIDIN-4-YLMETHYL)AMINO]BENZAMIDE | [CAS]
269390-69-4 | [Synonyms]
Valatinib
VEGFR-IN-1
VEGFR IN 1,VEGFRIN1
VEGFR Tyrosine Kinase
VEGFR Tyrosine Kinase Inhibitor II
VEGF RECEPTOR TYROSINE KINASE INHIBITOR II
N-(4-CHLOROPHENYL)-2-[(PYRIDIN-4-YLMETHYL)AMINO]BENZAMIDE
Benzamide, N-(4-chlorophenyl)-2-[(4-pyridinylmethyl)amino]- | [Molecular Formula]
C19H16ClN3O | [MDL Number]
MFCD09037563 | [MOL File]
269390-69-4.mol | [Molecular Weight]
337.8 |
| Chemical Properties | Back Directory | [Boiling point ]
463.6±40.0 °C(Predicted) | [density ]
1.331±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 50 mg/ml; DMSO: 50 mg/ml; DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml; Ethanol: 25 mg/ml | [form ]
A crystalline solid | [pka]
12.62±0.70(Predicted) | [color ]
White to off-white | [InChI]
1S/C19H16ClN3O/c20-15-5-7-16(8-6-15)23-19(24)17-3-1-2-4-18(17)22-13-14-9-11-21-12-10-14/h1-12,22H,13H2,(H,23,24) | [InChIKey]
GGPZCOONYBPZEW-UHFFFAOYSA-N | [SMILES]
Clc1ccc(cc1)NC(=O)c2c(cccc2)NCc3ccncc3 |
| Hazard Information | Back Directory | [Uses]
VEGFR Tyrosine Kinase Inhibitor II is an agent that potently inhibits kinase activities of KDR, Flt-1 and c-Kit. | [Biological Activity]
Cell permeable: yes''Primary Target
Kinase activities of KDRFlt-1 and c-Kit''Product competes with ATP.''Reversible: yes''Target IC50: 20 nM180 nM and 240 nM against kinase activities of KDRFlt-1 and c-Kitrespectively | [IC 50]
KDR: 0.02 μM (IC50); Flt-1: 0.18 μM (IC50); EGFR: 0.24 μM (IC50) |
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| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|