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N-Arachidonoyl-L-serine-d8 is an isotopic analogue of N-Arachidonoyl-L-serine (A765110), which is a novel neuroprotective endocannabinoid with weak affinity for CB1 and CB2 cannabinoid receptors. It is also a pro-angiogenic factor and a vessel dilator. Shows proneurogenic properties in vitro and in vivo in mice model of traumatic brain injury. | [References]
[1] T BISOGNO. N-acyl-dopamines: novel synthetic CB(1) cannabinoid-receptor ligands and inhibitors of anandamide inactivation with cannabimimetic activity in vitro and in vivo.[J]. Biochemical Journal, 2000, 351 Pt 3: 817-824.
[2] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
[3] GARRY MILMAN. N-arachidonoyl L-serine, an endocannabinoid-like brain constituent with vasodilatory properties.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2006: 2428-2433. DOI: 10.1073/pnas.0510676103
[4] SATOKO NAOE. Characterization of Lipid Profiles after Dietary Intake of Polyunsaturated Fatty Acids Using Integrated Untargeted and Targeted Lipidomics[J]. Metabolites, 2019. DOI: 10.3390/metabo9100241 |
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