| Identification | Back Directory | [Name]
1-Cyclopentyl-7-[(3,5-difluoro-4-hydroxyphenyl)amino]-1,4-dihydro-4,4-dimethyl-2H-pyrimido[4,5-d][1,3]oxazin-2-one | [CAS]
2755819-10-2 | [Synonyms]
1-Cyclopentyl-7-[(3,5-difluoro-4-hydroxyphenyl)amino]-1,4-dihydro-4,4-dimethyl-2H-pyrimido[4,5-d][1,3]oxazin-2-one | [Molecular Formula]
C19H20F2N4O3 | [MOL File]
2755819-10-2.mol | [Molecular Weight]
390.38 |
| Chemical Properties | Back Directory | [Boiling point ]
518.6±60.0 °C(Predicted) | [density ]
1.419±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) | [form ]
Solid | [pka]
7.78±0.36(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
RSK4-IN-1 is a potent RSK4 inhibitor with a IC50 value of 9.5 nM. RSK4-IN-1 has antitumor activity[1]. | [IC 50]
RSK4: 9.5 nM (IC50) | [References]
[1] Yuan Y, et al. Discovery, Optimization, and Structure-Activity Relationship Study of Novel and Potent RSK4 Inhibitors as Promising Agents for the Treatment of Esophageal Squamous Cell Carcinoma. J Med Chem. 2021 Sep 23;64(18):13572-13587. DOI:10.1021/acs.jmedchem.1c00969 |
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