ChemicalBook--->CAS DataBase List--->27570-38-3

27570-38-3

Request For Quotation
27570-38-3 Structure

27570-38-3 Structure
IdentificationBack Directory
[Name]

(22R)-5α,17α-Dihydroxy-6α,7α:22,26-diepoxyergosta-2,24-diene-1,26-dione
[CAS]

27570-38-3
[Synonyms]

Withanone
NSC 179884
WITHANONE(SH)
WITHANONE(SH)(NEW)
Withanone 27570-38-3
WITHANONE(P)(NEW)(27570-38-3)
(22R)-5α,17α-Dihydroxy-6α,7α:22,26-diepoxyergosta-2,24-diene-1,26-dione
(22R)-6α,7α-Epoxy-5,17,22-trihydroxy-1-oxo-5α-ergosta-2,24-dien-26-oic acid δ-lactone
(5a,6a,7a,22R)-6,7-Epoxy-5,17,22-trihydroxy-1-oxoergosta-2,24-dien-26-oic acid d-lactone
Ergosta-2,24-dien-26-oicacid, 6,7-epoxy-5,17,22-trihydroxy-1-oxo-, d-lactone, (5a,6a,7a,22R)-
Ergosta-2,24-dien-26-oic acid, 6,7-epoxy-5,17,22-trihydroxy-1-oxo-, δ-lactone, (5α,6α,7α,22R)-
[Molecular Formula]

C28H38O6
[MDL Number]

MFCD09264639
[MOL File]

27570-38-3.mol
[Molecular Weight]

470.6
Chemical PropertiesBack Directory
[Boiling point ]

653.7±55.0 °C(Predicted)
[density ]

1.264
[Fp ]

216℃
[storage temp. ]

-20°C
[solubility ]

Chloroform: soluble,Ethyl Acetate: slightly soluble,Methanol: slightly soluble
[form ]

neat
[pka]

12.98±0.70(Predicted)
[color ]

White to off-white
[InChIKey]

FAZIYUIDUNHZRG-PCTWTJKKSA-N
[SMILES]

O=C1[C@@]2(C)[C@]([C@@H](O3)[C@@H]3[C@]4([H])[C@]2([H])CC[C@@]5(C)[C@@]4([H])CC[C@@]5([C@H](C)[C@]6([H])OC(C(C)=C(C)C6)=O)O)(O)CC=C1
Safety DataBack Directory
[WGK Germany ]

3
[Storage Class]

11 - Combustible Solids
Hazard InformationBack Directory
[Uses]

Withanone is used in biological studies as it has therapeutic uses resulting in the reductase inhibition for cancer chemoprevention.
[in vivo]

Withanone (5-20 mg/kg; oral administration; daily; for 21 days; male Wistar rats) treatment shows significant improvement in the cognitive skill by inhibiting amyloid β-42 and attenuates the elevated levels of pro-inflammatory cytokines like TNF α, IL-1β, IL-6, MCP-1, Nitric oxide, lipid peroxidation and both β- and γ- secretase enzymatic activity. Administration of Withanone also significantly reverses the decline in acetyl choline and Glutathione (GSH) activity[1].

Animal Model:Male Wistar rats (20-24 weeks; 320-360 g) received ICV injection of STZ[1]
Dosage:5 mg/kg, 10 mg/kg and 20 mg/kg
Administration:Oral administration; daily; for 21 days
Result:Showed significant improvement in the cognitive skill by inhibiting amyloid β-42 and attenuated the elevated levels of pro-inflammatory cytokines like TNF alpha, IL-1β, IL-6, MCP-1, Nitric oxide, lipid peroxidation and both β- and γ- secretase enzymatic activity. Also significantly reversed the decline in acetyl choline and Glutathione (GSH) activity.
[IC 50]

NMDA Receptor
27570-38-3 suppliers list
Company Name: Chembest Research Laboratories Limited  
Telephone: 021-20908456
Website: www.biochembest.com
Company Name: Shanghai Tauto Biotech Co., Ltd.  
Telephone: 021-51320588
Website: http://www.tautobiotech.com/
Company Name: Quality Control Solutions Ltd.  
Telephone: 0755-66853366 13670046396
Website: www.qcsrm.com
Company Name: Sichuan Wei Keqi Biological Technology Co., Ltd.  
Telephone: 028-81700200 18116577057
Website: https://www.weikeqi-biotech.com/
Company Name: Finetech Industry Limited  
Telephone: 027-87465837 19945049750
Website: https://www.finetechchem.com/
Company Name: Nanjing LuoDa Chemical Co., Ltd  
Telephone: 025-66016961 13382082786;
Website: https://www.chemicalbook.com/ShowSupplierProductsList20138/0_EN.htm
Company Name: Shenzhen Polymeri Biochemical Technology Co., Ltd.  
Telephone: +86-400-002-6226
Website: https://www.rrkchem.com
Company Name: Finetech Industry Limited  
Telephone: +86-27-8746-5837 +86-18627785180
Website: https://www.finetechnology-ind.com/
Company Name: CONIER CHEM AND PHARMA LIMITED  
Telephone:
Website: http://www.conier.com/
Company Name: Aktin Chemicals, Inc.  
Telephone: 028-85159085 18080455027
Website: www.aktin.com/cn
Company Name: Energy Chemical  
Telephone: 021-58432009 400-005-6266
Website: http://www.energy-chemical.com
Company Name: Shanghai Sunway Pharmaceutical Technology Co.,Ltd.  
Telephone: 13611835272 13611835272
Website: www.sunwaypharm.cn/
Company Name: TargetMol Chemicals Inc.  
Telephone: 4008200310 15002144251
Website: https://www.targetmol.cn/
Company Name: Shanghai Tachizaki Biomedical Research Center  
Telephone: 18014399201
Website: http://www.chemlab-tachizaki.com/
Company Name: Wuhan Acumen Bio-Technology Co.,ltd  
Telephone: 027-027-16602739303 16602739303
Website: www.yjybiochem.com/
Company Name: RD International Technology Co., Limited  
Telephone: 18024082417
Website: www.ruidiresearch.com
Company Name: SHANGHAI ZZBIO CO., LTD.  
Telephone: 18019219489 18901678489
Website: www.zzsrm.cn/
Company Name: Changzhou Xianglong Pharmaceutical Technology Co., Ltd.,  
Telephone: 18915873328 18915873328
Website: www.xianglongpharm.com/
Tags:27570-38-3 Related Product Information
32911-62-9 56973-41-2 108030-78-0 63139-16-2 949172-13-8 362472-81-9 81644-34-0 118985-24-3 256520-90-8 57423-72-0 57485-60-6