| Identification | Back Directory | [Name]
(22R)-5α,17α-Dihydroxy-6α,7α:22,26-diepoxyergosta-2,24-diene-1,26-dione | [CAS]
27570-38-3 | [Synonyms]
Withanone
NSC 179884
WITHANONE(SH)
WITHANONE(SH)(NEW)
Withanone 27570-38-3
WITHANONE(P)(NEW)(27570-38-3)
(22R)-5α,17α-Dihydroxy-6α,7α:22,26-diepoxyergosta-2,24-diene-1,26-dione
(22R)-6α,7α-Epoxy-5,17,22-trihydroxy-1-oxo-5α-ergosta-2,24-dien-26-oic acid δ-lactone
(5a,6a,7a,22R)-6,7-Epoxy-5,17,22-trihydroxy-1-oxoergosta-2,24-dien-26-oic acid d-lactone
Ergosta-2,24-dien-26-oicacid, 6,7-epoxy-5,17,22-trihydroxy-1-oxo-, d-lactone, (5a,6a,7a,22R)-
Ergosta-2,24-dien-26-oic acid, 6,7-epoxy-5,17,22-trihydroxy-1-oxo-, δ-lactone, (5α,6α,7α,22R)- | [Molecular Formula]
C28H38O6 | [MDL Number]
MFCD09264639 | [MOL File]
27570-38-3.mol | [Molecular Weight]
470.6 |
| Chemical Properties | Back Directory | [Boiling point ]
653.7±55.0 °C(Predicted) | [density ]
1.264 | [Fp ]
216℃ | [storage temp. ]
-20°C | [solubility ]
Chloroform: soluble,Ethyl Acetate: slightly soluble,Methanol: slightly soluble | [form ]
neat | [pka]
12.98±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Withanone is used in biological studies as it has therapeutic uses resulting in the reductase inhibition for cancer chemoprevention. | [in vivo]
Withanone (5-20 mg/kg; oral administration; daily; for 21 days; male Wistar rats) treatment shows significant improvement in the cognitive skill by inhibiting amyloid β-42 and attenuates the elevated levels of pro-inflammatory cytokines like TNF α, IL-1β, IL-6, MCP-1, Nitric oxide, lipid peroxidation and both β- and γ- secretase enzymatic activity. Administration of Withanone also significantly reverses the decline in acetyl choline and Glutathione (GSH) activity[1]. | Animal Model: | Male Wistar rats (20-24 weeks; 320-360 g) received ICV injection of STZ[1] | | Dosage: | 5 mg/kg, 10 mg/kg and 20 mg/kg | | Administration: | Oral administration; daily; for 21 days | | Result: | Showed significant improvement in the cognitive skill by inhibiting amyloid β-42 and attenuated the elevated levels of pro-inflammatory cytokines like TNF alpha, IL-1β, IL-6, MCP-1, Nitric oxide, lipid peroxidation and both β- and γ- secretase enzymatic activity. Also significantly reversed the decline in acetyl choline and Glutathione (GSH) activity.
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| [IC 50]
NMDA Receptor |
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| Company Name: |
GK Chemicals
|
| Tel: |
+91-7207279444 +91-7207279444 |
| Website: |
www.www.info@gkchemicalss.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|