| Identification | Back Directory | [Name]
NH125 | [CAS]
278603-08-0 | [Synonyms]
NH125 USP/EP/BP
EEF-2 KINASE INHIBITOR
eEF-2 Kinase Inhibitor, NH125
3-Benzyl-1-hexadecyl-2-methyl-1H-imidazol-3-ium iodide
1-Hexadecyl-2-methyl-3-(phenylmethyl)-1H-imidazoliumiodide
eEF-2 Kinase Inhibitor, NH125 - CAS 278603-08-0 - Calbiochem | [Molecular Formula]
C27H45N2.I | [MDL Number]
MFCD07370143 | [MOL File]
278603-08-0.mol | [Molecular Weight]
524.567 |
| Chemical Properties | Back Directory | [Melting point ]
88.2-94.9 °C
| [storage temp. ]
−20°C
| [solubility ]
DMSO: 20 mg/mL
| [form ]
solid
| [color ]
white to off-white | [InChI]
1S/C27H45N2.HI/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-19-22-28-23-24-29(26(28)2)25-27-20-17-16-18-21-27;/h16-18,20-21,23-24H,3-15,19,22,25H2,1-2H3;1H/q+1;/p-1 | [InChIKey]
RVWOHCBHAGBLLT-UHFFFAOYSA-M | [SMILES]
[I-].CCCCCCCCCCCCCCCC[n+]1ccn(Cc2ccccc2)c1C |
| Hazard Information | Back Directory | [Uses]
NH125 is an inhibitor of multiple kinases. It kills methicillin-resistant Staphylococcus. | [Biological Activity]
Histidine protein kinase and eukaryotic elongation factor 2 (eEF-2) kinase (CaMK III) inhibitor (IC 50 = 60 nM) that displays 125-fold, > 1300-fold and > 1500-fold selectivity over PKC, PKA and CaMK II respectively. Exhibits anticancer activity in a variety of malignant cell lines (IC 50 values are 0.7 - 4.8 μ M) and blocks G 1 /S cell cycle progression. Also is an effective antibacterial agent in vitro (IC 50 = 6.6 μ M) and in vivo . | [Biochem/physiol Actions]
NH125 exhibits anti-proliferation activity against many cancer cells. It also exhibits antibacterial effects by inhibiting bacterial histidine protein kinase. | [IC 50]
CaMK III: 60 nM (IC50) | [storage]
Desiccate at -20°C | [References]
[1]. arora, s., et al., identification and characterization of an inhibitor of eukaryotic elongation factor 2 kinase against human cancer cell lines. cancer res, 2003. 63(20): p. 6894-9.
[2]. cheng, y., et al., integrated regulation of autophagy and apoptosis by eef2k controls cellular fate and modulates the efficacy of curcumin and velcade against tumor cells. autophagy, 2013. 9(2): p. 208-19.
[3]. usui, t., et al., eukaryotic elongation factor 2 kinase regulates the development of hypertension through oxidative stress-dependent vascular inflammation. am j physiol heart circ physiol, 2013. 305(5): p. h756-68. |
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