| Identification | Back Directory | [Name]
(R)-2-(1-HYDROXYETHYL)PYRIDINE | [CAS]
27911-63-3 | [Synonyms]
(R)-1-(2-PYRIDYL)-ETHANOL
(R)-1-(pyridin-2-yl)ethanol
(R)-2-(1-HYDROXYETHYL)PYRIDINE
(r)-α-methyl-2-pyridinemethanol
(aR)-a-Methyl-2-PyridineMethanol
"(R)-1-(pyridin-2- yl)ethan-1-ol"
(R)-(+)-2-(1-HYDROXYETHYL)PYRIDINE
(R)-2-(1-Hydroxyethyl)pyridine,98%
(R)-ALPHA-METHYL-2-PYRIDINEMETHANOL
(R)-alpha-Methylpyridine-2-methanol
2-Pyridinemethanol, α-methyl-, (αR)-
(alphaR)-alpha-Methyl-2-pyridinemethanol
(R)-1-(2-Pyridyl)-ethanol, (R)-2-(1-Hydroxyethyl)pyridine | [EINECS(EC#)]
246-680-4 | [Molecular Formula]
C7H9NO | [MDL Number]
MFCD04972322 | [MOL File]
27911-63-3.mol | [Molecular Weight]
123.15 |
| Questions And Answer | Back Directory | [Synthesis]
Step 1: Preparation of (R)-acetic acid-1-(pyridin-2-yl)-ethyl ester At room temperature, (R)-1-(pyridin-2-yl)-ethanol (21.2 mmol), 4A molecular sieve powder (3 g), vinyl acetate (6 mL), and lipase Candida Antarctica acrylic resin (0.87 g) were stirred overnight in i-Pr2O (40 mL). The solid residue was removed by filtration. Volatile substances were evaporated and purified by chromatography, eluting with hexane/EtOAc (7:3 to 1:1) to give a rapidly eluting colorless oily (R)-acetic acid-1-(pyridin-2-yl)-ethyl ester (50%). Step 2: Preparation of (R)-2-(1-hydroxyethyl)pyridine (R)-acetic acid-1-(pyridin-2-yl)-ethyl ester (9.620 mmol) was dissolved in methanol (50 mL), and then a solution of potassium carbonate (38.48 mmol) in water (10 mL) was added. The mixture was stirred at ambient temperature for 4 hours. It was diluted with brine, extracted three times with EtOAc, dried over anhydrous Na2SO4, filtered through a short silica gel pad, and concentrated under vacuum to give the desired intermediate (R)-2-(1-hydroxyethyl)pyridine as a colorless oily substance (89%). |
| Chemical Properties | Back Directory | [Appearance]
white crystals | [Boiling point ]
210.6±15.0 °C(Predicted) | [density ]
1.082±0.06 g/cm3(Predicted) | [refractive index ]
n20/D 1.528
| [storage temp. ]
2-8°C | [form ]
Solid | [pka]
13.55±0.20(Predicted) | [color ]
Pink | [Water Solubility ]
Soluble in ethanol and water. |
| Hazard Information | Back Directory | [Chemical Properties]
white crystals | [Uses]
(1R)?-?1-?(2-?Pyridinyl)?ethanol is a building block used in the synthesis of highly potent and selective chiral inhibitors of PDE5. |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
|