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612845-44-0

612845-44-0 Structure

612845-44-0 Structure
IdentificationMore
[Name]

(6-ETHOXYPYRIDIN-3-YL)BORONIC ACID
[CAS]

612845-44-0
[Synonyms]

2-ETHOXY-5-PYRIDINEBORONIC ACID
2-ETHOXY-5-PYRIDYL BORONIC ACID
2-ETHOXYPYRIDIN-5-YLBORONIC ACID
2-ETHOXYPYRIDINE-5-BORONIC ACID
(6-ETHOXYPYRIDIN-3-YL)BORONIC ACID
6-ETHOXYPYRIDINE-3-BORONIC ACID
Boronic acid, (6-ethoxy-3-pyridinyl)-(9CI)
6-Ethoxypyridine-3-boronicacid,98%
[EINECS(EC#)]

676-618-5
[Molecular Formula]

C7H10BNO3
[MDL Number]

MFCD06201032
[Molecular Weight]

166.97
[MOL File]

612845-44-0.mol
Questions And AnswerBack Directory
[Synthesis]

Synthetic route of (6-ETHOXYPYRIDIN-3-YL)BORONIC ACID

Parry PR et al. reported that (6-ETHOXYPYRIDIN-3-YL)BORONIC ACID can be prepared by reacting 2-ethoxypyridine with triisopropyl borate at -78 °C using butyllithium as a base, with a yield of 61%.

[Application]

2-Ethoxypyridine-5-boronic acid is a pharmaceutical intermediate that can be used to prepare BTK inhibitors. It can be prepared in one step by reacting 2-ethoxypyridine with triisopropyl borate.
Chemical PropertiesBack Directory
[Melting point ]

102-104°C
[Boiling point ]

322.5±52.0 °C(Predicted)
[density ]

1.20±0.1 g/cm3(Predicted)
[storage temp. ]

Keep in dark place,Sealed in dry,Room Temperature
[form ]

powder to crystal
[pka]

7.28±0.10(Predicted)
[color ]

White to Almost white
[BRN ]

9388808
[CAS DataBase Reference]

612845-44-0(CAS DataBase Reference)
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H315-H319-H335
[Precautionary statements ]

P261-P280a-P304+P340-P305+P351+P338-P405-P501a
[Risk Statements ]

R36/37/38:Irritating to eyes, respiratory system and skin .
[Safety Statements ]

S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
[WGK Germany ]

3
[HS Code ]

2933399990
Raw materials And Preparation ProductsBack Directory
[Raw materials]

Diethyl ether-->n-Butyllithium-->Triisopropyl borate-->5-Bromo-2-ethoxypyridine
Well-known Reagent Company Product InformationBack Directory
[Alfa Aesar]

6-Ethoxypyridine-3-boronic acid, 98%(612845-44-0)
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