| Identification | Back Directory | [Name]
[1,1′-Biphenyl]-4-carboxamide, 2-ethoxy-3′-fluoro-N-(1H-indazol-7-ylmethyl)-N-methyl- | [CAS]
2842012-69-3 | [Synonyms]
[1,1′-Biphenyl]-4-carboxamide, 2-ethoxy-3′-fluoro-N-(1H-indazol-7-ylmethyl)-N-methyl- | [Molecular Formula]
C24H22FN3O2 | [MOL File]
2842012-69-3.mol | [Molecular Weight]
403.45 |
| Chemical Properties | Back Directory | [Boiling point ]
621.6±55.0 °C(predicted) | [density ]
1.256±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
13.60±0.40(predicted) | [color ]
White to pink |
| Hazard Information | Back Directory | [Uses]
BAL-0028 is a reversible inhibitor of NLRP3 activation with an IC50 value of 25 nM. BAL-0028 binds closely to the NACHT domain of the NLRP3 with KD values of 104-123 nM. BAL-0028 can inhibit the secretion of IL-1β and has anti-inflammatory activity[1]. | [IC 50]
NLRP3: 25 nM (IC50) | [References]
[1] Hartman G, et al. The discovery of novel and potent indazole NLRP3 inhibitors enabled by DNA-encoded library screening. Bioorg Med Chem Lett. 2024 Feb 28;102:129675. DOI:10.1016/j.bmcl.2024.129675 |
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| Company Name: |
Shanghai Uchem Inc.
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| Tel: |
15618758386 15618758386 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList15300/0_EN.htm |
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