| Identification | Back Directory | [Name]
5,6-DIMETHYL-2-THIOURACIL | [CAS]
28456-54-4 | [Synonyms]
DMTU
Nsc 60687
Brn 0118811
5,6-Dimethylthiouracil
5,6-DIMETHYL-2-THIOURACIL
5,6-dimethyl-2-thio-uraci
Uracil, 5,6-dimethyl-2-thio-
5,6-diMethyl-2-sulfanylpyriMidin-4-ol
2-mercapto-5,6-dimethylpyrimidin-4-ol
2-Mercapto-5,6-dimethylpyrimidine-4-ol
4-pyrimidinol, 2-mercapto-5,6-dimethyl-
5,6-Dimethyl-4-hydroxy-2-thiopyrimidine
5,6-dimethyl-2-thioxo-1H-pyrimidin-4-one
2-Mercapto-5,6-dimethylpyrimidin-4(3H)-one
5,6-Dimethyl-4-hydroxy-2-thiopyrimidine 95%
5,6-Dimethyl-2(1H)-thioxopyrimidine-4(3H)-one
5,6-dimethyl-2-sulfanylidene-1H-pyrimidin-4-one
5,6-Dimethyl-2-thioxo-2,3-dihydropyrimidin-4(1H)
4(1H)-Pyrimidinone, 2,3-dihydro-5,6-dimethyl-2-thioxo-
5,6-Dimethyl-2-sulphanylpyrimidin-4-ol, 5,6-Dimethyl-4-hydroxy-2-mercapto-1,3-diazine | [Molecular Formula]
C6H8N2OS | [MDL Number]
MFCD00278872 | [MOL File]
28456-54-4.mol | [Molecular Weight]
156.21 |
| Chemical Properties | Back Directory | [Melting point ]
284-288 °C(lit.) | [density ]
1.2069 (rough estimate) | [refractive index ]
1.6490 (estimate) | [storage temp. ]
-20°C Freezer | [solubility ]
DMSO (Slightly), Methanol (Slightly, Heated) | [form ]
neat | [pka]
7.88±0.25(Predicted) | [color ]
White to Pale Yellow | [Water Solubility ]
1.373g/L(25 ºC) | [InChI]
1S/C6H8N2OS/c1-3-4(2)7-6(10)8-5(3)9/h1-2H3,(H2,7,8,9,10) | [InChIKey]
MEAKRQUSGACTFV-UHFFFAOYSA-N | [SMILES]
CC1=C(C)C(=O)NC(=S)N1 |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
36/37/38 | [Safety Statements ]
26-36 | [WGK Germany ]
3 | [RTECS ]
YQ9887000 | [HazardClass ]
IRRITANT | [HS Code ]
2933599590 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Description]
5,6-dimethyl-2-Thiouracil is a heterocyclic building block that has been used in the synthesis of anti-HIV-1 pyrimidinones. It has also been used as an internal standard for the quantification of thyreostats, including 2-thiouracil, in bovine plasma. | [Uses]
5,6-Dimethylthiouracil is a heterocyclic building block. | [References]
[1] NAVROTSKII M B. Synthesis and Anti-HIV-1 Activity of New 2-[(2-Phthalimidoethyl)thio]-4(3H)-pyrimidinone Derivatives[J]. Pharmaceutical Chemistry Journal, 2005, 29 1: 466-467. DOI: 10.1007/s11094-006-0002-1
[2] SCHMIDT K S. In-house validation and factorial effect analysis of a liquid chromatography–tandem mass spectrometry method for the determination of thyreostats in bovine blood plasma[J]. Analytical and Bioanalytical Chemistry, 2013, 406 3: 735-743. DOI: 10.1007/s00216-013-7517-6 |
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