| Identification | More | [Name]
2-Thiouracil | [CAS]
141-90-2 | [Synonyms]
2,3-dihydro-2-thioxo-4(1h)-pyrimidinone
2-MERCAPTO-4-HYDROXYPYRIMIDINE
2-MERCAPTO-4-PYRIMIDONE
2-THIOURACIL
4-HYDROXY-2-MERCAPTOPYRIMIDINE
4-HYDROXY-2-THIOPYRIMIDINE
DERACIL
2,3-dihydro-2-thioxo-4(1h)-pyrimidinon
2-mercapto-4(1h)-pyrimidinone
2-mercapto-4-pyrimidino
2-Mercapto-4-pyrimidinol
2-Mercaptopyrimid-4-one
2-Sulfanyl-4-pyrimidinol
2-Thio-1,3-pyrimidin-4-one
2-thio-2,4-(1h,3h)-pyrimidinedione
2-thio-4-oxo-1,3-pyrimidine
2-thio-4-oxypyrimidine
2-thio-6-oxypyrimidine
2-thio-uraci
2-TU | [EINECS(EC#)]
205-508-8 | [Molecular Formula]
C4H4N2OS | [MDL Number]
MFCD00006039 | [Molecular Weight]
128.15 | [MOL File]
141-90-2.mol |
| Chemical Properties | Back Directory | [Appearance]
white to cream fine crystalline powder | [Melting point ]
>300 °C (lit.) | [bulk density]
600kg/m3 | [density ]
1.368 (estimate) | [refractive index ]
1.7000 (estimate) | [storage temp. ]
2-8°C | [solubility ]
7.9g/l | [form ]
Fine Crystalline Powder | [pka]
pKa 7.46 (Uncertain) | [color ]
White to cream | [biological source]
synthetic | [Water Solubility ]
0.5 g/L | [λmax]
271nm(H2O)(lit.) | [Detection Methods]
HPLC | [Merck ]
14,9366 | [BRN ]
112227 | [InChI]
1S/C4H4N2OS/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8) | [InChIKey]
ZEMGGZBWXRYJHK-UHFFFAOYSA-N | [SMILES]
O=C1NC(=S)NC=C1 | [CAS DataBase Reference]
141-90-2(CAS DataBase Reference) | [IARC]
2B (Vol. Sup 7, 79) 2001 | [NIST Chemistry Reference]
2-Thiouracil(141-90-2) | [EPA Substance Registry System]
141-90-2(EPA Substance) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS08 | [Signal word ]
Warning | [Hazard statements ]
H351 | [Precautionary statements ]
P281 | [Hazard Codes ]
Xn,T | [Risk Statements ]
R40:Limited evidence of a carcinogenic effect.
R45:May cause cancer.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S36/37:Wear suitable protective clothing and gloves .
S53:Avoid exposure-obtain special instruction before use .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [WGK Germany ]
3 | [RTECS ]
YR1575000 | [Autoignition Temperature]
570°C | [TSCA ]
Yes | [HS Code ]
29335995 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Carc. 2 | [Safety Profile]
Moderately toxic by
ingestion. Human teratogenic effects by
unspecified routes: developmental
abnormalities of the central nervous system,
craniofacial area, and endocrine system.
Human reproductive effects by unspecified
route: effects on newborn, including viabllity
index changes. Experimental teratogenic
effects. Other experimental reproductive
effects. Questionable carcinogen with
experimental neoplastigenic and tumorigenic
data. Mutation data reported. When heated
to decomposition it emits very toxic fumes
of NOx and SOx. Used in the treatment of
hyperthyroidism, angina pectoris, and
congestive heart failure. See also
MERCAPTANS and KETONES. | [Hazardous Substances Data]
141-90-2(Hazardous Substances Data) |
| Hazard Information | Back Directory | [Chemical Properties]
white to cream fine crystalline powder | [Uses]
antiviral, thyroid depressant | [Uses]
Reagent used in the preparation of Antithyroid agents. | [Definition]
ChEBI: A nucleobase analogue that is uracil in which the oxo group at C-2 is replaced by a thioxo group. | [Biochem/physiol Actions]
2-Thiouracil is a thio-derivative of uracil, a pyrimidine nucleobase. It acts as an anticancer, antithyroid, and antiviral agent. 2-Thiouracil is a selective melanoma-seeker and competitive inhibitor of neuronal nitric oxide synthase. It also forms complexes with transition metals such as gold (Au), Chromium (Cr), Zinc (Zn), and Silver (Ag). | [Purification Methods]
Crystallise 2-thiouracil from water or EtOH. [Beilstein 24 H 323, 24 I 315, 24 II 171, 24 III/IV 1237.] |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
|
| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
|